| Description |
1 online resource (xii, 236 pages) : illustrations. |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
International review of child neurology series
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International review of child neurology.
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| Bibliography |
Includes bibliographical references and index. |
| Contents |
""CONTENTS""; ""AUTHORS� APPOINTMENTS""; ""FOREWORD""; ""1 LEUKODYSTROPHY AND MYELIN""; ""Introduction""; ""Definition of leukodystrophies""; ""2 MYELINATION IN HEALTH AND DISEASE""; ""Introduction""; ""Oligodendrocytes have a highly polarized shape""; ""Molecular composition of myelin and oligodendrocyte membranes""; ""Molecular mechanisms of myelin membrane formation""; ""Reciprocal interactions between axons and oligodendrocytes""; ""Summary and conclusions""; ""3 THE ROLE OF ASTROCYTES IN WHITE MATTER DISEASE""; ""Introduction""; ""Cellular lineage systems in the mammalian brain"" |
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""Astrocytes in development and adult life""""Leukodystrophies with distinct astrocyte pathology""; ""Possible mechanisms of white matter damage secondary to astrocyte dysfunction""; ""Summary and future perspectives""; ""4 MICROGLIA AND LEUKODYSTROPHIES""; ""Introduction""; ""Macrophage populations in the central nervous system""; ""Defining microglial activation""; ""Microglia in development and repair""; ""Brain colonization, self-renewal, and post-lesional recruitment of microglia""; ""Microglia in the pathogenesis of leukodystrophies""; ""Adrenoleukodystrophy"" |
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""Does VLCFA accumulation cause microglial activation?""""How does microglial activation relate to demyelination in adrenoleukodystrophy?""; ""Metachromatic leukodystrophy""; ""Microglia in globoid cell leukodystrophy (Krabbe disease)""; ""The role of microglia in transplantation""; ""Concluding remarks""; ""5 X-LINKED ADRENOLEUKODYSTROPHY""; ""Introduction""; ""Biochemical and molecular basis""; ""Clinical features""; ""Diagnosis""; ""Animal models""; ""Pathogenesis""; ""Therapy in adrenoleukodystrophy""; ""Expanded screening for asymptomatic individuals"" |
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""6 KRABBE DISEASE (GLOBOID CELL LEUKODYSTROPHY)""""Introduction""; ""Clinical features""; ""Diagnostic evaluation""; ""Pathological findings""; ""Biochemical findings""; ""Molecular genetics""; ""Newborn screening""; ""Studies in animal models""; ""Therapy""; ""Conclusions""; ""7 ALEXANDER DISEASE""; ""Introduction""; ""Clinical presentation""; ""MRI characteristics""; ""Pathology""; ""Diagnosis""; ""GFAP mutations""; ""Cases without GFAP mutations""; ""Recent cases""; ""Disease mechanisms""; ""Treatment""; ""Concluding remarks""; ""8 METACHROMATIC LEUKODYSTROPHY"" |
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""Classification and definition""""Incidence and prevalence""; ""Genetics""; ""Biochemical background""; ""Pathophysiology""; ""Clinical features""; ""Laboratory and genetic diagnosis""; ""Therapy""; ""9 CANAVAN DISEASE""; ""Introduction""; ""Molecular basis""; ""Clinical features""; ""Variant forms of the disease""; ""Differential diagnosis""; ""Pathogenesis and pathophysiology""; ""Prognosis""; ""Epidemiology""; ""Gene therapy""; ""Prevention""; ""10 PELIZAEUS�MERZBACHER DISEASE: GENETIC MODELS AND MECHANISMS""; ""Involvement of myelin proteolipid protein""; ""The PLP1 gene"" |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Metachromatic leukodystrophy.
|
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Metachromatic leukodystrophy. |
| Genre/Form |
Electronic books.
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Electronic books.
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| Added Author |
Raymond, Gerald V.
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| Other Form: |
Print version: Raymond, V. Gerald Leukodystrophies London : Mac Keith Press,c2014 9781907655098 |
| ISBN |
9781907655418 (electronic book) |
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1907655417 (electronic book) |
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9781907655098 |
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1907655093 |
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