| Description |
1 online resource (1 PDF file (xxiv, 403 pages)) : illustrations |
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text file |
| Note |
Title from PDF title page. |
| Bibliography |
Includes bibliographical references. |
| Summary |
On June 12 and 13, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to discuss the scientific tools and approaches being used for detecting and characterizing microbial species, and the roles of microbial genomics and metagenomics to better understand the culturable and unculturable microbial world around us. Through invited presentations and discussions, participants examined the use of microbial genomics to explore the diversity, evolution, and adaptation of microorganisms in a wide variety of environments; the molecular mechanisms of disease emergence and epidemiology; and the ways that genomic technologies are being applied to disease outbreak trace back and microbial surveillance. Points that were emphasized by many participants included the need to develop robust standardized sampling protocols, the importance of having the appropriate metadata (e.g., the sequencing platform used, sampling information, culture conditions), data analysis and data management challenges, and information sharing in real time. |
| Funding |
Financial support for this project was provided by the U.S. Department of Health and Human Services: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Centers for Disease Control and Prevention, and the Food and Drug Administration; U.S. Department of Defense, Department of the Army: Global Emerging Infections Surveillance and Response System, Medical Research and Materiel Command, and the Defense Threat Reduction Agency; U.S. Department of Veterans Affairs; U.S. Department of Homeland Security; U.S. Agency for International Development; Uniformed Services University of the Health Sciences; the Alfred P. Sloan Foundation, American Society for Microbiology; sanofi pasteur; Burroughs Wellcome Fund; GlaxoSmithKline; Infectious Diseases Society of America; and the Merck Company Foundation. |
| Contents |
Workshop overview -- Contributed manuscripts -- The microbial forensics pathway for use of massively parallel sequencing technologies -- Microbial virulence as an emergent property: consequences and opportunities -- Microbial genome sequencing to understand pathogen transmission -- Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission -- Design considerations for home and hospital microbiome studies -- Sequencing errors, diversity estimates, and the rare biosphere -- Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar -- Big data in biology: pitfalls when using shotgun metagenomics to define hypotheses about microbial communities -- High-throughput bacterial genome sequencing: embarrassment of choice, a world of opportunity -- Evidence for several waves of global transmission in the seventh cholera pandemic -- Multi-partner interactions in corals in the face of climate -- Change genomic transition to pathogenicity in chytrid fungi -- Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses -- Genomic approaches to studying the human microbiota -- Sequence analysis of the human virome in febrile and afebrile children. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Genome, Microbial. |
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Genetics, Microbial. |
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Metagenomics. |
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Microbiological Phenomena -- genetics. |
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Metagenomics.
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Metagenomics. |
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Microbial genomics.
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Microbial genomics. |
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Communicable diseases.
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Communicable diseases. |
| Genre/Form |
Congress.
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Electronic books.
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Electronic books.
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Conference papers and proceedings.
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Conference papers and proceedings.
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| Added Author |
Olsen, LeighAnne, author.
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Wizemann, Theresa M., author.
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Institute of Medicine (U.S.). Forum on Microbial Threats, sponsoring body.
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Workshop on the Science and Applications of Microbial Genomics (2012 : Washington, D.C.)
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| Other Form: |
Online version: Science and applications of microbial genomics. Washington, D.C. : The National Academies Press, [2013] 9780309268196 (OCoLC)843098196 |
| ISBN |
9780309268196 |
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0309268192 |
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9780309268202 |
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0309268206 |
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