| Description |
1 online resource (257 pages). |
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text file |
| Series |
Frontiers in Clinical Drug Research - Diabetes and Obesity
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Frontiers in Clinical Drug Research - Diabetes and Obesity.
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| Contents |
PREFACE ; List of Contributors ; Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope ; INTRODUCTION; The Discovery of Exendin-4; Fundamental Aspects of Exendin-4; Present Status of Exendin-4 for the Treatment of Type 2 Diabetes; INTERACTION OF EXENDIN-4 WITH GLP-1 RECEPTOR; GLP-1 Receptor and Its Dimerization; Exendin-4 Binding to GLP-1 Receptor; MODIFICATION OF EXENDIN-4 AND RELATED APPLICATIONS; Improved Stability and Binding Affinity; Improved Oral Bioavailability; Vitamin Conjugation; Low Molecular Weight Chitosan Conjugation. |
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Cholera Toxin B Subunit FusionExtended Half-life and Long Acting Preparations; Dimeric Exendin-4; Bile Acid Conjugation; Poly (Ethylene Glycol) Conjugation; Human Serum Albumin Conjugation; Albumin-Binding Domain Conjugation; Hyaluronate Conjugation; Mixed Strategies; CONCLUSION AND FUTURE PERSPECTIVES; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; The Growth Hormone/Insulin-like Growth Factor System in the Management of Diabetes and Obesity ; INTRODUCTION; Overview of the GH/IGF System; Metabolic Actions of the GH/IGF System ; THERAPEUTIC CONSIDERATIONS; Obesity. |
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Severe Insulin ResistanceType 2 Diabetes; Type 1 Diabetes; CONCLUSION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Insulin, Cardiovascular Function and Long-Term Diabetic Complications ; INTRODUCTION; The Role of Hyperglycemia; Insulin and Muscle Capillary Function; Muscle Sympathetic Nerve Activity; Insulin and Capillary Recruitment; NO, Nitric Oxide, Endothelium-derived Relaxing Factor; Insulin, Skeletal Muscle Blood Flow and Obesity; Kidney: Insulin and Albumin Excretion; Kidney: Albumin Excretion and Diabetic Nephropathy; Long-term Diabetic Complications; Drug Discovery Science. |
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CONCLUSIONCONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Pharmacological Relevance of Novel Biomarkers Associated with Diabetes-mellitus Related Infertility ; 1. INTRODUCTION; 2. TESTICULAR PHYSIOLOGY AND ANATOMY; 2.1. Sertoli Cells: Morphology and Structure; 2.2. Spermatogenesis: A Brief Overview; 2.3. Regulation of Spermatogenesis; 2.3.1. Hormonal Control of Spermatogenesis; 3. TESTICULAR METABOLIC CO-OPERATION; 3.1. The Metabolism of Sertoli Cells; 3.2. The Metabolic Support of Developing Germ Cells. |
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3.3. The Metabolic Requirements of Spermatozoa: Considerations about Glucose Metabolism4. IMPACT OF DIABETIC STAGES IN MALE FERTILITY; 4.1. Glycemic Trajectories: From the High-risk State to the Established Diabetes Mellitus; 4.2. The Effects of Diabetes Mellitus in Male Fertility: A Clinical Perspective; 5. DIABETES MELLITUS AS A THREAT FOR TESTICULAR METABOLISM; 5.1. Testicular Oxidative Stress Induced by Progressive Diabetic Stages; 6. TESTICULAR METABOLIC CO-OPERATION AS POTENTIAL PHARMACOLOGIC TARGET TO COUNTERACT DIABETES MELLITUS -- ASSOCIATED SUBFERTILITY AND INFERTILITY. |
| Note |
7. INSIGHTS IN THE EPIGENETIC OUTCOMES OF DIABETES MELLITUS ON MALE FERTILITY. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Diabetes.
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Diabetes. |
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Diabetes -- Treatment.
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Diabetes -- Treatment. |
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Obesity.
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Obesity. |
| Genre/Form |
Electronic books.
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| Added Author |
Rahman, Atta-ur-, 1942-
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| Other Form: |
Print version: Atta-ur-Rahman. Frontiers in Clinical Drug Research - Diabetes and Obesity volume 3. Sharjah : Bentham Science Publishers, ©2016 9781681082486 |
| ISBN |
9781681082479 (electronic book) |
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1681082470 (electronic book) |
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