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Title The HLA factsbook / Steven G.E. Marsh, Peter Parham, Linda D. Barber.

Publication Info. San Diego : Academic Press, [2000]
©2000

Item Status

Description 1 online resource (xiii, 398 pages) : illustrations.
Physical Medium polychrome
Description text file
Series Factsbook series
Factsbook series.
Bibliography Includes bibliographical references and index.
Contents Preface. -- Abbreviations. -- The Introductory Chapters: -- Introduction. -- Human Leukocyte Antigens (HLA) Determine Histocompatibility in Transplantation. -- The Organisation of HLA Genes Within the HLA Complex. -- HLA Class I Antigens and Alleles: Workshops and Nomenclature. -- HLA Class II Antigens and Alleles: Workshops and Nomenclature. -- HLA Typing at the DNA Level. -- HLA Class I and II Molecules Present Peptide Antigens to Different Types of T Cell. -- HLA Class I Molecules Control Natural Killer Cell Function. -- Three-Dimensional Structures of HLA Class I Molecules. -- Three-Dimensional Structures of HLA Class II Molecules. -- HLA Polymorphism, Peptide Binding Motifs and T-Cell Epitopes. -- Evolution and Anthropology of HLA. -- HLA and Disease. -- Alloreactions in Transplantation. -- The HLA Class I and Class II Loci.
Summary The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Key Features * Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists * Up-to-date, complete listing of HLA alleles * Invaluable reference resource for immunologists, geneticists, and cell biologists * Combines both structural and functional information, which has never been compiled in a single reference book previously * Serological specificity of allotypes * Identity of material sequenced including ethnic origin * Database accession numbers * Population distribution * Peptide binding specificities * T cell epitopes * Amino acid sequences of allotypes * Key references.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject HLA histocompatibility antigens -- Handbooks, manuals, etc.
HLA histocompatibility antigens.
Genre/Form Handbooks and manuals.
Subject HLA Antigens -- genetics.
Genre/Form Electronic books.
Handbooks and manuals.
Added Author Marsh, Steven G. E.
Parham, Peter, 1950-
Barber, Linda D.
Other Form: Print version: HLA factsbook. San Diego : Academic Press, ©2000 0125450257 9780125450256 (DLC) 99065746 (OCoLC)42622188
ISBN 9780125450256
0125450257
9781435605152 (electronic book)
1435605152 (electronic book)