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Bestseller
BestsellerE-book
Author Beard, Daniel A., 1971-

Title Biosimulation : simulation of living systems / Daniel A. Beard.

Publication Info. Cambridge ; New York : Cambridge University Press, 2012.

Item Status

Description 1 online resource.
Physical Medium polychrome
Description text file
Series Cambridge texts in biomedical engineering
Cambridge texts in biomedical engineering.
Bibliography Includes bibliographical references and index.
Contents Cover; Biosimulation; Series; Title; Copyright; Contents; Preface; Extracts; 1: Introduction to simulation of biological systems; Overview; 1.1 Modeling approaches; 1.2 An introductory example: biochemistry of a home aquarium; 1.2.1 First model: a nonmechanistic analysis; 1.2.2 Nonmechanistic analysis with noise; 1.2.3 Mechanistic modeling; 1.3 Recapitulation and lessons learned; Problems; 2: Transport and reaction of solutes in biological systems; Overview; 2.1 Well-mixed systems: compartmental modeling; 2.2 Passive flow of water, solutes, and electrical current across membranes.
2.2.1 Basic equations2.2.2 Example: volume changes in isolated glomeruli; 2.3 Simulating chemical reactions; 2.3.1 Example: synthesis of ethanol from xylose; 2.4 Distributed transport modeling; 2.4.1 Flowing systems: the advection equation; 2.4.2 Reaction-diffusion systems; 2.4.3 Advection-reaction-diffusion systems; 2.5 Recapitulation and lessons learned; Problems; 3: Physiologically based pharmacokinetic modeling; Overview; 3.1 Introduction to lumped compartmental PBPK modeling; 3.1.1 Basic equations; 3.1.2 Comparison of distributed and lumped transport models.
3.1.3 Quasi-steady model reduction3.1.4 Lumped versus distributed transport modeling: a final word; 3.2 Overview of the mammalian circulatory system; 3.3 Whole-body PBPK simulation; 3.4 Example: uptake and delivery of matrine in rat; 3.4.1 A PBPK model for rat; 3.4.2 Model parameters; 3.4.3 Flow-limited transport; 3.4.4 Model validation and discrimination; 3.5 Recapitulation and lessons learned; Problems; 4: Cardiovascular systems simulation; Overview; 4.1 The Frank-Starling mechanism of heart; 4.2 An analysis of the physiological factors that control cardiac output.
4.2.1 Guyton's model of the systemic circulation4.2.2 What the model tells us about the relationship between flow and right atrial pressure; 4.2.3 How the simple Guyton model is commonly misinterpreted; 4.3 Pulsatile mechanics of the circulatory system; 4.3.1 Time-varying elastance models of the heart; 4.3.2 Simulation of the aortic pressure waveform; 4.4 Dynamic changes in blood pressures and flows; 4.4.1 Baroreceptor control of systemic pressure; 4.5 Mechanisms of hypertension; 4.6 Recapitulation and lessons learned; Problems.
5: Chemical reaction systems: thermodynamics and chemical equilibriumOverview; 5.1 Temperature, pressure, and entropy; 5.1.1 Microstates and macrostates; 5.1.2 Example: a simple two-state system; 5.1.3 Relationship between temperature and entropy; 5.1.4 Relationship between pressure and entropy; 5.2 Free energy under constant-temperature and constant-volume conditions; 5.3 Free energy under constant-temperature and constant-pressure conditions; 5.4 Thermodynamic ensembles, partition functions, and driving forces; 5.5 Chemical reactions, stoichiometry, and equilibrium constants; 5.6 Acids, bases, and buffers.
Summary A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Biophysics -- Computer simulation.
Biophysics.
Computer simulation.
Biophysics -- Simulation methods.
Simulation methods.
Biomedical engineering -- Computer simulation.
Biomedical engineering -- Computer simulation.
Biomedical engineering.
Medical sciences -- Case studies.
Medical sciences.
Genre/Form Case studies.
Case Reports.
Electronic books.
Case studies.
Other Form: Print version: Beard, Daniel A., 1971- Biosimulation. Cambridge ; New York : Cambridge University Press, 2012 9780521768238 (DLC) 2011046839 (OCoLC)761858511
ISBN 9781139379489 (electronic book)
1139379488 (electronic book)
9781139375191
1139375199
9781139045582 (electronic book)
113904558X (electronic book)
9781139376624
1139376624
9780521768238 (Cloth)
0521768233 (Cloth)
Standard No. 9786613640789