| Description |
1 online resource (xxii, 292 pages) : illustrations. |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
Issues in toxicology
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Issues in toxicology.
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| Summary |
The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutations are thought to be becoming more prevalent as a result of: exposure to chemicals in the environment, anti cancer regimes that use genotoxic agents and assisted conception techniques. In addition to the increasing frequency of mutations in the general population, attention is also being given to the effects of epigenetic events on future generations. Male-mediated Developmental Toxicity discusses these issues comprehensively and includes further analysis on the fundamental mechanisms of mutations. With both clinical and experimental sections, written by leading experts in the field, this book will appeal to both medical practitioners and researchers. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Epigenetic transgenerational actions of endocrine disruptors through the male germ-line -- Reproductive outcomes among men treated for cancer -- Paediatric cancer : an indicator of familial cancer risk? -- What harms the developing male reproductive system? -- Links between paternal smoking and childhood cancer -- Feasibility study of metal effects on the X:Y ratio in human sperm -- Use of the sperm chromatin structure assay (SCSA) as a diagnostic tool in the human infertility clinic -- Safety of sperm for use in intra-cytoplasmic sperm injection -- Male-mediated F1 effects in mice exposed to di(2-ethylhexyl)phthalate (DEHP) -- Prevention of adverse effects of cancer treatment on the germline -- Molecular changes in sperm and early embryos after paternal exposure to a chemotherapeutic agent -- Transmissible genetic risk causing tumours in mice and humans -- Heritable effects on DNA damage following paternal F0 germline irradiation -- Influence of DNA methylation and genomic imprinting in the male germ line on pregnancy outcome -- Information content of ejaculate spermatozoa and its potential utility in toxicology and infertility based research programmes -- Origin of paternal mutations -- Redox regulation of dna damage in the male germ line -- Advances in the direct measurements of partial chromosomal duplication, deletions and breaks in human and murine sperm by sperm fish -- Radiation-induced transgenerational instability in mice -- New genetic information generated by endogenous reverse transcription in sperm cells -- Sperm abnormalities in exposed humans -- Oestrogenic compounds and oxidative stress -- DNA repair capacities in testicular cells of rodents and man -- Closing panel discussion. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Mutagenesis.
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Mutagenesis. |
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Antibody diversity.
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Antibody diversity. |
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Spermatogenesis. |
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Antineoplastic Agents. |
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Environmental Exposure. |
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Genetic Predisposition to Disease. |
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Mutagenesis. |
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Neoplasms. |
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Pregnancy Outcome. |
| Genre/Form |
Congress.
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Electronic books.
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| Added Author |
Brinkworth, Martin H.
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Anderson, Diana.
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| Other Form: |
Print version: International Conference on Male-Mediated Developmental Toxicity (3rd : 2005 : University of Bradford). Male-mediated developmental toxicity. Cambridge, UK : RSC Publishing, ©2007 9780854048472 (DLC) 2010287214 (OCoLC)123111201 |
| ISBN |
9781847557643 (electronic book) |
|
1847557643 (electronic book) |
|
9780854048472 |
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0854048472 |
|
