LEADER 00000cam a2200649Ma 4500 
001    ocn797852346 
003    OCoLC 
005    20160527041553.9 
006    m     o  d         
007    cr cn||||||||| 
008    120611s2012    si a    ob    001 0 eng d 
019    794328417|a794902675|a817084761 
020    9789814299817|q(electronic bk.) 
020    9814299812|q(electronic bk.) 
020    1280669187 
020    9781280669187 
020    |z9814299804 
020    |z9789814299800 
035    (OCoLC)797852346|z(OCoLC)794328417|z(OCoLC)794902675
       |z(OCoLC)817084761 
040    E7B|beng|epn|cE7B|dN$T|dOCLCQ|dDEBSZ|dOCLCQ|dSTF|dYDXCP
       |dUKDOC|dOCLCQ|dOCLCF|dEBLCP|dIDEBK|dCGU|dCDX|dOCLCQ 
049    RIDW 
050  4 QH588.S83|bH43 2012eb 
072  7 MED|x075000|2bisacsh 
072  7 SCI|x036000|2bisacsh 
072  7 MJD|2bicssc 
082 04 612.17|223 
090    QH588.S83|bH43 2012eb 
245 00 Heart regeneration|h[electronic resource] :|bstem cells 
       and beyond /|cedited by Felix B. Engel. 
260    Singapore :|bWorld Scientific Pub. Co.,|c2012. 
300    1 online resource (xx, 372 pages :) :|bcolor illustrations
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
504    Includes bibliographical references and index. 
505 0  I. Introduction to cardiac disease / Erin Bohula and 
       Richard T. Lee -- II. Growth and differentiation of the 
       developing heart / Bram van Wijk [and others] -- III. Does
       heart regeneration occur? A. Cardiac regeneration in the 
       newt / Thilo Borchardt and Thomas Braun. B. Zebrafish 
       heart regeneration / Robert J. Major and Kenneth D. Poss. 
       C. Regenerative potential of the mammalian heart / May 
       Liang-Lam and William C. Claycomb -- IV. Repopulation of 
       the heart with new cardiomyocytes. A. Induction of 
       cardiomyocyte proliferation / Machteld J. van Amerongen 
       and Felix B. Engel. B. Multipotent progenitor cells in 
       regenerative cardiovascular medicine / Jason T. Lam, 
       Alessandra Moretti and Karl-Ludwig Laugwitz. C. 
       Circulating progenitor cells / Masamichi Koyanagi and 
       Stefanie Dimmeler. D. Pluripotent stem cells for cardiac 
       repair / Kara White Moyes, Scott D. Lundy and Michael A. 
       Laflamme -- V. What is the paracrine effect of stem cells?
       A. Stem cell therapy for heart repair: the paracrine 
       paradigm / Massimiliano Gnecchi, Maria Mirotsou and Victor
       J. Dzau. B. Delivery systems to the heart / Kathryn M. 
       Rafferty and Michael E. Davis -- VI. How to create an 
       artificial heart ex vivo? A. The mechanical heart / JoAnn 
       Lindenfeld and Patricia A. Kelly. B. Engineered heart 
       tissue / Thomas Eschenhagen and Wolfram-Hubertus 
       Zimmermann -- VII. The complexity of organ regeneration / 
       Tatyana Novoyatleva and Felix B. Engel -- VIII. Cell 
       therapy trials in patients with coronary heart disease / 
       Kai C. Wollert. 
520    Injured mammalian hearts do not regenerate but scar. This 
       is a major medical problem, as ischemic heart disease is 
       among the leading causes of morbidity and mortality 
       worldwide. Essential clues for human heart repair are 
       uncovered when zebrafish and newt are found to regenerate 
       cardiac muscle after injury. This book presents the major 
       advances of the last decade in the field of cardiac 
       regeneration. These recent advances include: demonstration
       that zebrafish, a genetically tractable system, can 
       regenerate heart; the identification of several new stem 
       cell populations in the heart; demonstration that stem 
       cells can be used to improve heart function; and 
       demonstration that induction of cardiomyocyte 
       proliferation is a realistic future option to repair 
       injured hearts. This book also provides detailed reviews 
       of the research on model organisms capable of heart 
       regeneration as well as innovative translational research 
       to achieve regeneration in mammals, that comprises work on
       blood born stem cells, endogenous cardiac stem cells, 
       paracrine factors, reawakening of cardiomyocyte 
       proliferation, and bioengineering. More importantly, the 
       book, in the concluding chapter, dovetails the studies 
       with a comprehensive overview of clinical trials. 
590    eBooks on EBSCOhost|bEBSCO eBook Subscription Academic 
       Collection - North America 
650  0 Stem cells|xResearch. 
650  0 Heart|xDiseases|xTreatment. 
655  4 Electronic books. 
700 1  Engel, Felix B. 
776 08 |iPrint version:|aEngel, Felix B.|tHeart Regeneration : 
       Stem Cells and Beyond.|dSingapore : World Scientific, 
       ©2012|z9789814299800 
856 40 |uhttps://rider.idm.oclc.org/login?url=http://
       search.ebscohost.com/login.aspx?direct=true&scope=site&
       db=nlebk&AN=457227|zOnline eBook. Access restricted to 
       current Rider University students, faculty, and staff. 
856 42 |3Instructions for reading/downloading this eBook|uhttp://
       guides.rider.edu/ebooks/ebsco 
948    |d20160607|cEBSCO|tebscoebooksacademic|lridw 
994    92|bRID