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Title Heart regeneration [electronic resource] : stem cells and beyond / edited by Felix B. Engel.

Imprint Singapore : World Scientific Pub. Co., 2012.

Item Status

Description 1 online resource (xx, 372 pages :) : color illustrations
Bibliography Includes bibliographical references and index.
Contents I. Introduction to cardiac disease / Erin Bohula and Richard T. Lee -- II. Growth and differentiation of the developing heart / Bram van Wijk [and others] -- III. Does heart regeneration occur? A. Cardiac regeneration in the newt / Thilo Borchardt and Thomas Braun. B. Zebrafish heart regeneration / Robert J. Major and Kenneth D. Poss. C. Regenerative potential of the mammalian heart / May Liang-Lam and William C. Claycomb -- IV. Repopulation of the heart with new cardiomyocytes. A. Induction of cardiomyocyte proliferation / Machteld J. van Amerongen and Felix B. Engel. B. Multipotent progenitor cells in regenerative cardiovascular medicine / Jason T. Lam, Alessandra Moretti and Karl-Ludwig Laugwitz. C. Circulating progenitor cells / Masamichi Koyanagi and Stefanie Dimmeler. D. Pluripotent stem cells for cardiac repair / Kara White Moyes, Scott D. Lundy and Michael A. Laflamme -- V. What is the paracrine effect of stem cells? A. Stem cell therapy for heart repair: the paracrine paradigm / Massimiliano Gnecchi, Maria Mirotsou and Victor J. Dzau. B. Delivery systems to the heart / Kathryn M. Rafferty and Michael E. Davis -- VI. How to create an artificial heart ex vivo? A. The mechanical heart / JoAnn Lindenfeld and Patricia A. Kelly. B. Engineered heart tissue / Thomas Eschenhagen and Wolfram-Hubertus Zimmermann -- VII. The complexity of organ regeneration / Tatyana Novoyatleva and Felix B. Engel -- VIII. Cell therapy trials in patients with coronary heart disease / Kai C. Wollert.
Summary Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury. This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Stem cells -- Research.
Heart -- Diseases -- Treatment.
Genre/Form Electronic books.
Added Author Engel, Felix B.
Other Form: Print version: Engel, Felix B. Heart Regeneration : Stem Cells and Beyond. Singapore : World Scientific, ©2012 9789814299800
ISBN 9789814299817 (electronic bk.)
9814299812 (electronic bk.)