The Niakhar high-titer measles vaccine trial, 1987-1990 / by Michel Garenne, in collaboration with Odile Leroy, Jean-Pierre Beau, Ibra Séne, Hilton Whittle, Abdourahmane Sow.
This study reports the methodology and findings of a randomized controlled vaccine trial conducted in Senegal in 1987-1990. Two high-titer measles vaccines of different strains (Edmonston-Zagreb and Schwarz) were compared with a standard vaccine (the Schwarz strain) among infants aged 5 to 10 months. Comparison focused on clinical efficacy, immunogenicity and safety. Although both high-titer vaccines induced an immunogenic response even when given at the age of 5 months, they induced a lower level of antibodies, had more vaccine failures, and were not safe, inducing an excess mortality within.
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