LEADER 00000cam a2200565 i 4500 001 on1153078564 003 OCoLC 005 20240126125653.0 006 m o d 007 cr cnu---unuuu 008 200502s2020 mau ob 001 0 eng d 019 1162603180|a1176255041 020 0674245288|q(electronic bk.) 020 9780674245280|q(electronic bk.) 020 |z9780674281363|q(hardcover) 020 |z0674281365|q(hardcover) 035 (OCoLC)1153078564|z(OCoLC)1162603180|z(OCoLC)1176255041 037 22573/ctv250t5cp|bJSTOR 040 EBLCP|beng|erda|epn|cEBLCP|dN$T|dYDX|dN$T|dEBLCP|dUPP |dOCLCF|dDEGRU|dWAU|dUKAHL|dCUV|dSFB|dOCLCO|dRDF|dOCLCO |dOCL|dJSTOR|dOCL|dOCLCO|dAAA|dOCLCO|dOCLCQ|dK6U|dOCLCQ |dOCLCO 041 1 eng|hfre 049 RIDW 050 4 QH506 072 7 SCI|x049000|2bisacsh 072 7 SCI|x034000|2bisacsh 072 7 SCI|x086000|2bisacsh 082 04 572.8|223 090 QH506 100 1 Morange, Michel,|eauthor. 240 10 Histoire de la biologie moléculaire.|lEnglish 245 14 The black box of biology :|ba history of the molecular revolution /|cMichael Morange ; translated by Matthew Cobb. 264 1 Cambridge :|bHarvard University Press,|c2020 300 1 online resource (vi, 522 pages) 336 text|btxt|2rdacontent 337 computer|bc|2rdamedia 338 online resource|bcr|2rdacarrier 504 Includes bibliographical references and index 505 0 Part I. The birth of molecular biology: The roots of the new science -- The one gene-one enzyme hypothesis -- The chemical nature of the gene -- The phage group -- The birth of bacterial genetics -- The crystallization of the tobacco mosaic virus -- Enter the physicists -- The influence of the Rockefeller Foundation -- Physical techniques in molecular biology -- The role of physics -- Part II. The development of molecular biology: The discovery of the double helix -- Deciphering the genetic code -- The discovery of messenger RNA -- The French School -- Part III. The expansion of molecular biology: Normal science -- Genetic engineering -- Split genes and splicing -- The discovery of oncogenes -- From DNA polymerase to the amplification of DNA -- Part IV. Beyond molecular biology?: The molecularization of biology and medicine -- Protein structure -- The rise of developmental biology -- Molecular biology and evolution -- Gene therapy -- The central place of RNA -- Epigenetics -- Sequencing the human genome -- Systems biology and synthetic biology -- Images, representations and metaphors in molecular biology 520 "Over the past forty years a molecular vision has transformed biology. What began as an attempt to understand and explain life by looking at organisms at the microscopic level soon led to the rapid development of pathbreaking new technologies and discoveries that would change our understanding of science. In The Black Box of Biology Michel Morange shows that what led to this incredible transformation of biology was not an accumulation of new results, but the molecularization of a large part of biology. The expansion led to a cluster of explanatory tools and mechanisms used across biology and medicine. Yet, it was the fusion of the principles and concepts of molecular biology with those of other subdisciplines that led to the most decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs like the Human Genome sequencing program, and the emergence of new disciplines like synthetic biology, systems biology, and epigenetics. Yet the progress was not one sided. Morange reveals that molecular biology opened the black box of biology, and in turn, the discipline has been enriched by its expansion"--|cProvided by publisher 588 0 Online resource, title from digital title page (viewed on February 23, 2021). 590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic Collection - North America 650 0 Molecular biology|xHistory. 650 7 SCIENCE|xLife Sciences|xMolecular Biology.|2bisacsh 650 7 Molecular biology|2fast 655 7 History|2fast 700 1 Cobb, Matthew,|etranslator. 776 08 |iPrint version:|aMorange, Michel|sHistoire de la biologie moléculaire. English|tBlack box of biology|dCambridge, Massachusetts : Harvard University Press, 2020 |z9780674281363|w(DLC) 2019040562|w(OCoLC)1111379480 856 40 |uhttps://rider.idm.oclc.org/login?url=https:// search.ebscohost.com/login.aspx?direct=true&scope=site& db=nlebk&AN=2413310|zOnline ebook via EBSCO. Access restricted to current Rider University students, faculty, and staff. 856 42 |3Instructions for reading/downloading the EBSCO version of this ebook|uhttp://guides.rider.edu/ebooks/ebsco 948 |d20240319|cEBSCO|tEBSCOebooksacademic NEW 1-26-24 6521 |lridw 994 92|bRID