| Description |
1 online resource (1 PDF file (xxvi, 316 pages)) : color illustrations |
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text file |
| Bibliography |
Includes bibliographical references. |
| Summary |
The 2014-2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014-2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak. Integrating Clinical Research into Epidemic Response: The Ebola Experience assesses the value of the clinical trials held during the 2014-2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events. |
| Funding |
This activity was supported by Contract No. HHSP233201400020B/HHSP23337042 with the Assistant Secretary for Preparedness and Response, U.S. Department of Health and Human Services. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. |
| Contents |
Introduction -- Conducting clinical research during an epidemic -- Assessment of therapeutic trials -- Assessment of vaccine trials -- Strengthening capacity for response and research -- Engaging communities in research and response -- Facilitating international coordination and collaboration -- Appendices. Study approach and methods -- Clinical trial designs -- Ethical principles for research with human subjects -- Biographical sketches of committee members and staff. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Ebola virus disease -- Treatment -- Africa, West.
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Ebola virus disease. |
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West Africa. |
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Clinical trials -- Africa, West.
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Clinical trials. |
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Guinea. |
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Liberia. |
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Sierra Leone. |
| Genre/Form |
Electronic books.
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Technical reports.
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Technical reports.
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| Added Author |
Busta, Emily R., editor.
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Mancher, Michelle, editor.
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Cuff, Patricia A., editor.
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McAdam, Keith P. W. J., editor.
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Keusch, Gerald, editor.
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National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Clinical Trials During the 2014-2015 Ebola Outbreak.
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| Other Form: |
Print version: Integrating clinical research into epidemic response. Washington, D.C. : National Academies Press, [2017] 0309457769 (OCoLC)989051665 |
| ISBN |
9780309457774 |
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0309457777 |
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9780309457767 |
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0309457769 |
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