LEADER 00000cam a2200733Ii 4500 001 ocn994612372 003 OCoLC 005 20190111050727.3 006 m o d 007 cr ||||||||||| 008 170724t20172017dcua ob 000 0 eng d 019 995759121|a1000445638|a1000593211|a1001454667|a1001786789 020 9780309458634|q(electronic book) 020 0309458633|q(electronic book) 020 |z9780309458627 020 |z0309458625 035 (OCoLC)994612372|z(OCoLC)995759121|z(OCoLC)1000445638 |z(OCoLC)1000593211|z(OCoLC)1001454667|z(OCoLC)1001786789 040 SCB|beng|erda|epn|cSCB|dUAB|dEBLCP|dYDX|dMERUC|dCUS|dIDB |dN$T|dMERER|dOCLCQ|dOCLCO|dOCLCA|dBUF|dOCLCO|dOCLCF|dEZ9 |dOCLCQ|dOCLCA 043 n-us--- 049 RIDW 050 4 RC649|b.A67 2017 072 7 HEA|x039000|2bisacsh 072 7 MED|x014000|2bisacsh 072 7 MED|x022000|2bisacsh 072 7 MED|x112000|2bisacsh 072 7 MED|x045000|2bisacsh 082 04 616.4|223 090 RC649|b.A67 2017 245 00 Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals /|cCommittee on Endocrine-Related Low- Dose Toxicity, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies. 264 1 Washington, DC :|bThe National Academies Press,|c[2017] 264 4 |c©2017 300 1 online resource (xviii, 404 pages) :|billustrations (some color) 336 text|btxt|2rdacontent 337 computer|bc|2rdamedia 338 online resource|bcr|2rdacarrier 347 text file|2rdaft 500 "A consensus study report of the National Academies of Sciences, Engineering, Medicine." 500 Title from PDF title page (National Academies Press, viewed July 24, 2017). 504 Includes bibliographical references. 505 0 Introduction -- Strategy for evaluating low-dose effects - - Phthalates and male reproductive-tract development -- Effect of polybrominated diphenyl ethers on neurodevelopment -- Lessons learned and reflections on the statement of task -- Appendix A: Biosketches of the Committee on Endocrine-Related Low-Dose Toxicity -- Appendix B; Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose Toxicity -- Appendix C: Supporting materials for the phthalate (animal) systematic review -- Appendix D: Supporting materials for the phthalate (human) systematic review -- Appendix E: Supporting materials for the PBDE (animal) systematic review -- Appendix F: Supporting materials for the PBDE (human) systematic review. 520 1 "To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity- testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects"--Publisher's description. 590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic Collection - North America 650 0 Endocrine toxicology|0https://id.loc.gov/authorities/ subjects/sh91001248|vCongresses.|0https://id.loc.gov/ authorities/subjects/sh99001533 650 0 Endocrine disrupting chemicals|0https://id.loc.gov/ authorities/subjects/sh2008020233|xToxicity testing|0https ://id.loc.gov/authorities/subjects/sh2002007678 |vCongresses.|0https://id.loc.gov/authorities/subjects/ sh99001533 650 0 Systematic reviews (Medical research)|0https://id.loc.gov/ authorities/subjects/sh97007019|vCongresses.|0https:// id.loc.gov/authorities/subjects/sh99001533 650 7 Endocrine toxicology.|2fast|0https://id.worldcat.org/fast/ 909746 650 7 Endocrine disrupting chemicals.|2fast|0https:// id.worldcat.org/fast/1745376 650 7 Toxicity testing.|2fast|0https://id.worldcat.org/fast/ 1153336 650 7 Systematic reviews (Medical research)|2fast|0https:// id.worldcat.org/fast/1141436 655 2 Congress.|0https://id.nlm.nih.gov/mesh/D016423 655 4 Electronic books. 655 7 Conference papers and proceedings.|2fast|0https:// id.worldcat.org/fast/1423772 655 7 Conference papers and proceedings.|2lcgft|0https:// id.loc.gov/authorities/genreForms/gf2014026068 710 2 National Academies of Sciences, Engineering, and Medicine (U.S.).|bCommittee on Endocrine-Related Low-Dose Toxicity, |0https://id.loc.gov/authorities/names/n2017188205 |eauthor. 711 2 Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose Toxicity|d(2016 :|cWashington, D.C.) 776 08 |iPrint version:|z0309458625|z9780309458627 |w(OCoLC)995768793 776 08 |iPrint version:|tApplication of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals.|dWashington, DC : the National Academies Press, [2017]|z9780309458627 |w(OCoLC)994612372 856 40 |uhttps://rider.idm.oclc.org/login?url=http:// search.ebscohost.com/login.aspx?direct=true&scope=site& db=nlebk&AN=1568471|zOnline eBook via EBSCO. Access restricted to current Rider University students, faculty, and staff. 856 42 |3Instructions for reading/downloading the EBSCO version of this eBook|uhttp://guides.rider.edu/ebooks/ebsco 901 MARCIVE 20231220 948 |d20190118|cEBSCO|tEBSCOebooksacademic NEW 1-11-19 6702 |lridw 994 92|bRID