Title Overcoming challenges to develop countermeasures against aerosolized bioterrorism agents : appropriate use of animal models / Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents, Board on Life Sciences, Institute for Laboratory Animal Research, Division of Earth and Life Studies.

Publication Info.	Washington D.C. : National Academies Press, [2006]
	©2006

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Description	1 online resource (xvi, 71 pages) : illustrations, charts (some color)
Physical Medium	polychrome
Description	text file
Bibliography	Includes bibliographical references.
Contents	Selection or development of an animal model -- Generation and characterization of aerosolized agents -- Dosimetry considerations -- Experimental design -- Resource issues.
Summary	The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies -- including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) -- be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.
Local Note	eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject	Bioterrorism -- Research.
	Bioterrorism.
	Research.
	Chemical warfare.
	Chemical warfare.
	Toxicity testing.
	Toxicity testing.
	Toxicology.
	Toxicology.
	Toxicology -- Animal models.
	Toxicology -- Animal models.
Genre/Form	Electronic books.
	Electronic books.
Added Author	National Research Council (U.S.). Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents.
	National Research Council (U.S.). Board on Life Sciences.
	Institute for Laboratory Animal Research (U.S.)
Other Form:	Print version: Overcoming challenges to develop countermeasures against aerosolized bioterrorism agents. Washington D.C. : National Academies Press, ©2006 9780309660938 (DLC) 2006285761 (OCoLC)73723261
ISBN	9780309660938 (electronic book)
	0309660939 (electronic book)
	9780309102117 (paperback)
	0309102111 (paperback)

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