LEADER 00000cam a2200721Ka 4500 001 ocn743002497 003 OCoLC 005 20160527040931.5 006 m o d 007 cr cnu---unuuu 008 110727s2011 dcua ob 000 0 eng d 019 712594100|a738849629|a743413562|a816844561|a923283511 020 9780309211949|q(electronic book) 020 0309211948|q(electronic book) 020 1283135159 020 9781283135153 020 |z9780309211932 020 |z030921193X 035 (OCoLC)743002497|z(OCoLC)712594100|z(OCoLC)738849629 |z(OCoLC)743413562|z(OCoLC)816844561|z(OCoLC)923283511 040 N$T|beng|epn|cN$T|dNATAP|dE7B|dIDEBK|dOCLCQ|dOHS|dOCLCQ |dWVH|dOCLCQ|dZMC|dOCLCQ|dCOO|dYDXCP|dOCLCQ|dNLGGC|dEJB |dCDX|dOCLCQ|dEBLCP|dDEBSZ|dOCLCQ 043 n-us--- 049 RIDW 050 4 TP248.F6|bN387 2011eb 072 7 TEC|x009010|2bisacsh 082 04 661/.85|223 090 TP248.F6|bN387 2011eb 110 2 National Research Council (U.S.).|bCommittee to Review EPA's Draft IRIS Assessment of Formaldehyde.|0https:// id.loc.gov/authorities/names/no2011102893 245 10 Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde /|cCommittee to Review EPA's Draft IRIS Assessment of Formaldehyde, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies. 246 30 Formaldehyde 264 1 Washington, D.C. :|bNational Academies Press,|c[2011] 264 4 |c©2011 300 1 online resource (xiii, 190 pages) :|billustrations 336 text|btxt|2rdacontent 337 computer|bc|2rdamedia 338 online resource|bcr|2rdacarrier 340 |gpolychrome|2rdacc 347 text file|2rdaft 504 Includes bibliographical references. 505 00 |tREVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF FORMALDEHYDE --|tIntroduction -- |tReview of Methods --|tToxicokinetics and Modes of Action of Formaldehyde --|tPortal-of-Entry Health Effects -- |tSystemic Health Effects --|tReference Concentrations for Noncancer Effects and Unit Risks for Cancers --|tA Roadmap for Revision --|gAppendix A:|tBiographic Information on the Committee to Review EPA'S Draft IRIS Assessment of Formaldehyde --|gAppendix B:|tWeight-of-Evidence Descriptions from U.S. Environmental Protection Agency Guidelines. 520 Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in some foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Integrated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process. 588 0 Print version record. 590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic Collection - North America 610 10 United States.|bEnvironmental Protection Agency.|0https:// id.loc.gov/authorities/names/n79079597 610 17 United States.|bEnvironmental Protection Agency.|2fast |0https://id.worldcat.org/fast/534882 610 24 United States.|bEnvironmental Protection Agency. 650 0 Formaldehyde|0https://id.loc.gov/authorities/subjects/ sh85050805|xToxicology.|0https://id.loc.gov/authorities/ subjects/sh2002007679 650 0 Formaldehyde|0https://id.loc.gov/authorities/subjects/ sh85050805|xRisk assessment.|0https://id.loc.gov/ authorities/subjects/sh00006258 650 7 Formaldehyde|xToxicology.|2fast|0https://id.worldcat.org/ fast/932939 650 7 Formaldehyde.|2fast|0https://id.worldcat.org/fast/932927 650 7 Risk assessment.|2fast|0https://id.worldcat.org/fast/ 1098146 650 12 Formaldehyde|xtoxicity.|0https://id.nlm.nih.gov/mesh/ D005557Q000633 650 12 Formaldehyde|xadverse effects.|0https://id.nlm.nih.gov/ mesh/D005557Q000009 650 22 Risk Assessment.|0https://id.nlm.nih.gov/mesh/D018570 655 4 Electronic books. 710 1 United States.|bEnvironmental Protection Agency.|0https:// id.loc.gov/authorities/names/n79079597 776 08 |iPrint version:|tReview of the Environmental Protection Agency's Draft Iris Assessment of Formaldehyde.|dNatl Academy Pr 2011|z9780309211932|w(OCoLC)730412364 856 40 |uhttps://rider.idm.oclc.org/login?url=http:// search.ebscohost.com/login.aspx?direct=true&scope=site& db=nlebk&AN=372485|zOnline eBook. Access restricted to current Rider University students, faculty, and staff. 856 42 |3Instructions for reading/downloading this eBook|uhttp:// guides.rider.edu/ebooks/ebsco 901 MARCIVE 20231220 948 |d20160616|cEBSCO|tebscoebooksacademic|lridw 994 92|bRID