| Description |
1 online resource (xiv, 330 pages) : illustrations |
| Physical Medium |
polychrome |
| Description |
text file |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Chaperone function / R.J. Ellis -- Intracellular disposition of mitochondrial molecular chaperones / R.S. Gupta [and others] -- Novel pathways of protein secretion / G. Chimini, A. Rubartelli -- Moonlighting proteins / C.J. Jeffery -- Molecular chaperones / B. Henderson, A. Shamaei-Tousi -- Cell-cell signalling properties of the chaperonins / A.R.M. Coates -- Toll-like receptor-dependent activation of antigen presenting cells by Hsp60, Hsp70 and Gp96 / R.M. Vabulas, H. Wagner -- Regulation of signal transduction by intracellular and extracellular Hsp70 / A. Asea, S. Calderwood -- Hsp72 and cell signalling / M.Y. Sherman -- Heat shock proteins, their cell surface receptors and effect on the immune system / T. Lehner [and others] -- Molecular chaperone-cytokine interactions at the transcriptional level / A. Stephanou, D.S. Latchman -- Heat shock protein release and naturally-occurring exogenous heat shock proteins / J. Frostegård, A.G. Pockley -- Hsp27 as an anti-inflammatory protein / K. Laudanski, A. De, C. Miller-Graziano -- Bip, a negative immune regulator involved in rheumatoid arthritis / V.M. Corrigal, G.S. Panayi -- Neuroendocrine aspects of the molecular chaperones ADNF and ADNP / I. Gozes [and others] -- Heat shock proteins regulate by both molecular and network cross-reactivity / F.J. Quintana, I.R. Cohen -- Heat shock protein fusions / L. Mizzen, J. Neefe -- Molecular chaperones as inducers of tumour immunity / P.P. Banerjee, Z. Li -- Gazing into the crystal ball / L. Hightower. |
| Summary |
This book reviews current understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first-and-foremost protein-folding molecules. The current paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Molecular chaperones.
|
|
Molecular chaperones. |
| Genre/Form |
Electronic books.
|
| Added Author |
Henderson, Brian (Professor)
|
|
Pockley, A. Graham (Alan Graham), 1960-
|
| Other Form: |
Print version: Molecular chaperones and cell signalling. Cambridge, UK ; New York : Cambridge University Press, 2005 9780521836548 (DLC) 2005000664 (OCoLC)57422382 |
| ISBN |
9780511345159 (electronic book) |
|
0511345151 (electronic book) |
|
9780511546310 (electronic book) |
|
0511546319 (electronic book) |
|
0521836549 (hardback) |
|
9780521836548 |
|
9780521177474 (paperback) |
|
0521177472 (paperback) |
|
1281108480 |
|
9781281108487 |
|
