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Title Molecular and Cellular Biology of Pathogenic Trypanosomatids / edtied by Marcelo Santos da Silva.

Publication Info. Sharjah : Bentham Science Publishers, 2017.

Item Status

Description 1 online resource (612 pages) : color illustrations.
Physical Medium polychrome
Description text file
Series Frontiers in Parasitology ; volume 1
Frontiers in Parasitology ; v. 1.
Contents FOREWORD ; PREFACE ; List of Contributors ; The Cellular Organization of Trypanosomatids During Life Cycle ; INTRODUCTION; NUCLEUS; Nuclear Organization; Nuclear Pore Complex; Nuclear Lamin; Nucleolus; Chromatin; Histone Post-Translational Modifications (PTM) in Trypanosomes; Chromatin Regulation at Specific Genomic Regions; DNA Modifications; CYTOSKELETON; FLAGELLUM; MITOCHONDRION; Organization of Mitochondrial DNA; Protein Synthesis in the Mitochondrion; ENDOPLASMIC RETICULUM; GLYCOSOMES; MEMBRANE TRAFFICKING AND THE GOLGI COMPLEX; LYSOSOMES AND ACIDIC ORGANELLES; Reservosomes.
AcidocalcisomesCONCLUDING REMARKS; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; ABBREVIATIONS; REFERENCES; Trypanosomatid Genome Organization and Ploidy ; INTRODUCTION; EPIDEMIOLOGICAL CONTEXT OF THE TRYPANOSOMATIDS; Leishmania: The Causative Agent of Leishmaniasis; T. cruzi: The Causative Agent of Chagas Disease; T. brucei: The Causative Agent of Sleeping Sickness; LIFE CYCLE; The Life Cycle of Leishmania spp.; The Life Cycle of Trypanosoma cruzi ; The Life Cycle of Trypanosoma brucei ; TAXONOMY OF THE TRITRYPS; GENOME ORGANIZATION; Trypanosomatid Comparative Genomics; Leishmania Genomic Features.
Trypanosoma GenusTrypanosoma brucei Sub-species Complex; T. cruzi and Close Related Parasites; CONCLUDING REMARKS; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; ABBREVIATIONS; REFERENCES; Chromosomes Ends and Telomere Biology of Trypanosomatids ; INTRODUCTION; OVERALL STRUCTURE OF TELOMERES; THE STRUCTURE OF SUBTELOMERIC REGIONS; Size, Sequence Content and Organization of T. cruzi and T. rangeli Subtelomeres; Organization of Leishmania Subtelomeres; Telomeric DNA Modification, the Base J; FORMATION OF NEW TELOMERES IN T. CRUZI ; TELOMERE MAINTENANCE IN TRYPANOSOMATIDS; ARTIFICIAL CHROMOSOMES.
CONCLUDING REMARKSCONFLICT OF INTEREST; ACKNOWLEDGEMENTS; ABBREVIATIONS; REFERENCES; Nuclear and Kinetoplast DNA Replication in Trypanosomatids ; INTRODUCTION; DNA POLYMERASES; Trypanosomatids DNA Polymerases; NUCLEAR DNA REPLICATION; Recognition of Origins and Assembly/Activation of Pre-replication Complex; Origins Recognition, Licensing and Firing in Trypanosomatids; Replication Fork Progress; Telomere Replication and Elongation; Control and Regulation of Nuclear DNA Replication; KINETOPLAST DNA REPLICATION; Components of kDNA: Mini- and Maxicircles.
KDNA Replication: Mechanisms and Proteins InvolvedMechanisms of kDNA Replication; Proteins Involved in kDNA Replication; Control and Regulation of kDNA Replication; Redox Regulation of UMSBP Binding; Expression of mRNA; CONCLUDING REMARKS; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; ABBREVIATIONS; REFERENCES; Genome Maintenance in Trypanosomatids ; INTRODUCTION; The Genomes of Kinetoplastids; NUCLEOTIDE EXCISION REPAIR: MECHANISTIC STREAMLINING AND NEOFUNCTIONALISATION; THE DUAL ROLE OF MISMATCH REPAIR IN DNA REPAIR AND IN THE OXIDATIVE STRESS RESPONSE; BASE EXCISION REPAIR.
Note HOMOLOGOUS RECOMBINATION: ADAPTATIONS FOR GENOME VARIATION?
Bibliography Includes bibliographical references and index.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Trypanosomatidae.
Trypanosomatidae.
Genre/Form Electronic books.
Added Author Silva, Marcelo Santos da.
Cano, Maria Isabel N.
Other Form: Print version: Silva, Marcelo Santos da. Molecular and Cellular Biology of Pathogenic Trypanosomatids. Sharjah : Bentham Science Publishers, ©2017 9781681084060
ISBN 9781681084053 (electronic book)
1681084058 (electronic book)