| Description |
1 online resource. |
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text file |
| Series |
DNA and RNA : properties and modifications, functions and interactions, recombination and applications
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Cell biology research progress
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DNA and RNA-properties and modifications, functions and interactions, recombination and applications.
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Cell biology research progress.
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| Note |
Includes bibliographical references and index. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
DNA REPAIR NEW RESEARCH; DNA REPAIR NEW RESEARCH; LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA; CONTENTS; PREFACE; Chapter 1: DNA REPAIR AS THE PRIMARY ADAPTIVE FUNCTION OF SEX IN BACTERIA AND EUKARYOTES; ABSTRACT; INTRODUCTION; DNA DAMAGE, A BASIC PROBLEM FOR LIFE; BACTERIAL TRANSFORMATION IS AN ADAPTIVE SEXUAL PROCESS; COMPETENCE DEVELOPMENT IS USUALLY ASSOCIATED WITH STRESSFUL CONDITIONS; BACTERIAL TRANSFORMATION, AS AN ADAPTATION FOR DNA REPAIR; SEX WAS PRESENT EARLY IN THE EVOLUTION OF EUKARYOTES; THE SEXUAL CYCLE IN EUKARYOTIC MICROORGANISMS OCCURS UNDER STRESSFUL CONDITIONS. |
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THE SEXUAL CYCLE IN UNICELLULAR OR SIMPLE MULTICELLULAR EUKARYOTES AS A RESPONSE TO DNA DAMAGING CONDITIONSBACTERIAL TRANSFORMATION AND EUKARYOTIC MEIOSIS HAVE FUNDAMENTAL SIMILARITIES; ROLE OF THE RECA PROTEININ TRANSFORMATION; ROLE OF RECA ORTHOLOGS IN MEIOSIS OF UNICELLULAR EUKARYOTES; ROLE OF RECA ORTHOLOGS IN MEIOSIS OF COMPLEX MULTICELLULAR EUKARYOTES; DNA DAMAGE INCREASES MEIOTIC RECOMBINATION; CROSSOVER AND NON-CROSSOVER RECOMBINATION: IMPLICATIONS FOR VARIATION THEORIES; THE FUNCTION OF NCO RECOMBINATION; MEIOTIC HRR IS ESSENTIAL FOR FERTILITY AND EARLY EMBRYONIC SURVIVAL. |
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DNA DAMAGES ARE REPAIRED BY HRR DURING MEIOSIS AND MITOSISDURING MEIOSIS HRR LIKELY REMOVES A CLASS OF DNA DAMAGES THAT CANNOT BE ACCURATELY REMOVED DURING MITOSIS; WHAT ARE THE CONSEQUENCES OF DNA DAMAGES IN THE MITOTIC DIVISIONS PRECEDING MEIOSIS IN THE GERM LINE OF MULTICELLULAR ORGANISMS?; CROSSOVER HOTSPOTS IN MEIOSIS; EVOLUTIONARY FORCES MAINTAINING SEX; BENEFITS OF OUTCROSSING SEX; AGING, SEX AND REJUVENATION; PARTHENOGENESIS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: DNA REPAIR AS A NOVEL THERAPEUTIC TARGET IN BREAST CANCER; ABSTRACT; 1. INTRODUCTION. |
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2. DNA-DAMAGING AGENTS IN CANCER TREATMENTS3. DNA-DAMAGE CHECKPOINTS; 4. DNA REPAIR PATHWAYS; 4.1. Homologous Recombination Repair (HRR); 4.2. Non-Homologous End Joining; 4.3. Base Excision Repair; 4.4. Nucleotide Excision Repair; 4.5. Mismatch Repair; 4.6. Direct Repair; 5. DNA REPAIR PROTEINS AS THERAPEUTICTARGETS IN CANCER; 6. TARGETING DNA DOUBLE STRAND BREAKS REPAIR; 6.1. Inhibition of the HRR Pathway by Targeting ATM; 6.2. Inhibition of the NHEJ Pathway by Targeting DNA-PKs; 7. DNA-REPAIR PROTEINS DEREGULATED IN BREAST CANCER. |
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8. THERAPEUTIC INTERVENTION OF BRCA1 AND BRCA2 DEFICIENT BREAST TUMORS9. POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3: DNA REPAIR IN THE NERVOUS SYSTEM:A NEW RESEARCH FORNEUROLOGICAL DISORDERS; ABSTRACT; INTRODUCTION; 1. CLASSICAL OVERVIEW OF DNA REPAIR DEFICIENCY AND NEURODEGENERATIVE DISORDERS; 2. DEFECTIVE DNA REPAIR IN MAJOR NEURODEGENERATIVE DISEASES; 3. DEFECTIVE DNA REPAIR IN NEURODEVELOPMENTAL DISORDERS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 4: TARGETING THE BRCA1 DNA REPAIR PATHWAY FOR CANCER CHEMOTHERAPY; ABSTRACT. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Language |
English. |
| Subject |
DNA repair.
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DNA repair. |
| Genre/Form |
Electronic books.
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Electronic books.
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| Added Author |
Kimura, Sakura.
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Shimizu, Sora.
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| Other Form: |
Print version: DNA repair New York : Nova Science Publishers, Inc., [2012] 9781621007562 (hardcover) (DLC) 2011038504 |
| ISBN |
9781621008088 ebook |
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1621008088 |
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9781621007562 hardcover |
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1621007561 |
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