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Title Oxidative folding of proteins : basic principles, cellular regulation and engineering / edited by Matthias J. Feige.

Publication Info. [Cambridge] : Royal Society of Chemistry, [2018]

Item Status

Description 1 online resource.
Physical Medium polychrome
Description text file
Series Chemical biology ; 9
Chemical biology series ; no. 9.
Summary With contributions from experts in the field, this book provides a comprehensive overview of the oxidative folding of cysteine-rich proteins.
Contents Section 1: Principles and Analysis of Disulfide Bond Formation; Disulfide Bonds in Protein Folding and Stability; Techniques to Monitor Disulfide Bond Formation and the Reduction Potential of Cysteine-Cystine Couples In vitro and In vivo; Real-time Detection of Thiol Chemistry in Single Proteins; Analysis of Disulfide Bond Formation in Therapeutic Proteins; Section 2: Disulfide Bonds in Peptides and Proteins: Structure, Function and Evolution; Evolutionary Adaptations to Cysteine-rich Peptide Folding; In vitro Refolding of Proteins; Allosteric Disulfide Bonds; Section 3: Oxidative Folding in the Cell; Disulfide Bond Formation and Isomerization in Escherichia coli; Disulfide Bond Formation in Mitochondria; Structural Insights into Disulfide Bond Formation and Protein Quality Control in the Mammalian Endoplasmic Reticulum; Mechanisms of Oxidative Protein Folding and Thiol-dependent Quality Control: Tales of Cysteines and Cystines; Disulfide Bond Formation Downstream of the Endoplasmic Reticulum; Section 4: Oxidative Folding and Cellular/Organism Homeostasis; How Microbes Cope with Oxidative Stress; Disulfide Bond Formation in the Endoplasmic Reticulum; Redox Regulation of Hsp70 Chaperone Function in the Endoplasmic Reticulum; Thioredoxin and Cellular Redox Systems: Beyong Protein Disulfide Bond Reduction; Section 5: Engineering Covalent Linkages in Peptides and Proteins; Stabilization of Peptides and Proteins by Engineered Disulfide Bonds; Genetic Code Expansion Approaches to Introduce Artificial Covalent Bonds into Proteins in Vivo
Bibliography Includes bibliographical references and index.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Protein folding.
Protein folding.
Genre/Form Electronic books.
Added Author Feige, Matthias J., 1979- editor.
Other Form: Print version: Oxidative folding of proteins. [Cambridge] : Royal Society of Chemistry, [2018] 1782629904 9781782629900 (OCoLC)1023050667
ISBN 9781788013253 (electronic book)
1788013255 (electronic book)
9781782629900
1782629904
9781788014854 (EPub)