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BestsellerE-book

Title Sequence-specific DNA binding agents / edited by Michael Waring.

Publication Info. Cambridge : Royal Society of Chemistry, [2006]
©2006

Item Status

Description 1 online resource (xi, 258 pages) : illustrations (some color).
Physical Medium polychrome
Description text file
Series RSC biomolecular sciences
RSC biomolecular sciences.
Bibliography Includes bibliographical references and index.
Contents DNA recognition by triple helix formation / David A. Rusling, Tom Brown, and Keith R. Fox -- Interfacial inhibitors of human topoisomerase I / Christophe Marchand and Yves Pommier -- Diversity of topoisomerase I inhibitors for cancer chemotherapy / Nathalie Dias and Christian Bailly -- Slow DNA binding / L. Marcus Wilhelmsson, Per Lincoln, and Bengt Nordén -- DNA gene targeting using Peptide Nucleic Acid (PNA) / Peter E. Nielsen -- Actinomycin D : sixty years of progress in characterizing a sequence-selective DNA-binding agent / David E. Graves -- Thermal denaturation of drug-DNA complexes : tools and tricks / Jonathan B. Chaires and Xiaochun Shi -- Computer simulations of drug-DNA interactions : a personal journey / Federico Gago -- The discovery of G-quadruplex telomere targeting drugs / Stephen Neidle -- The mechanism of action of telomestatin, a G-quadruplex-interactive compound / Daekyu Sun and Laurence H. Hurley -- Structural features of the specific interactions between nucleic acids and small organic molecules / Alexander Serganov and Dinshaw J. Patel.
Summary This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity. The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target. The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Language English.
Subject DNA-drug interactions.
DNA-drug interactions.
DNA-binding proteins.
DNA-binding proteins.
Gene targeting.
Gene targeting.
Drug targeting.
Drug targeting.
Chemotherapy.
Chemotherapy.
Genre/Form Electronic books.
Electronic books.
Added Author Waring, Michael J.
Other Form: Print version: Sequence-specific DNA binding agents. Cambridge : RSC Pub., ©2006 9780854043705 (DLC) 2007360567 (OCoLC)72867758
ISBN 9781847555304 (electronic book)
1847555306 (electronic book)