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Title Protein-nucleic acid interactions : structural biology / edited by Phoebe A. Rice and Carl C. Correll.

Publication Info. Cambridge : Royal Society of Chemistry, [2008]
©2008

Item Status

Description 1 online resource (xvii, 397 pages) : illustrations (some color).
Physical Medium polychrome
Description text file
Series RSC biomolecular sciences
RSC biomolecular sciences.
Bibliography Includes bibliographical references and index.
Contents Introduction / Carl C. Correll and Phoebe A. Rice -- Role of water and effects of small ions in site-specific protein-DNA interactions / Linda Jen-Jacobson and Lewis A. Jacobson -- Structural basis for sequence-specific DNA recognition by transcription factors and their complexes / Manqing Hong and Ronen Marmorstein -- Indirect readout of DNA sequence by proteins / Catherine L. Lawson and Helen M. Berman -- Single-stranded nucleic acid (SSNA)-binding proteins / Martin P. Horvath -- DNA junctions and their interaction with resolving enzymes / David M.J. Lilley -- RNA-protein interactions in ribonucleoprotein particles and ribonucleases / Hong Li -- Bending and compaction of DNA by proteins / Reid C. Johnson, Stefano Stella and John K. Heiss -- Mode of action of proteins with RNA chaperone activity / Sabine Stampfl [and others] -- Structure and function of DNA topoisomerases / Ken C. Dong and James M. Berger -- DNA transposases / Fred Dyda and Alison Burgess Hickman -- Site-specific recombinases / Gregory D. Van Duyne -- DNA nucleases / Nancy C. Horton -- RNA-modifying enzymes / Adrian R. Ferré-D'amaré.
Summary Written by a team of experts, this book bridges the gap between the DNA- and RNA- views of protein-nucleic acid recognition which are often treated as separate fields. The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between DNA bending and indirect readout. Horvath lays out the fundamentals of protein recognition of single stranded DNA and single stranded RNA, and describes how they apply in a detailed analysis of telomere end binding proteins. Nucleic acids adopt more complex structures - Lilley describes the conformational properties of helical junctions, and how proteins recognize and cleave them. Because RNA readily folds due to the stabilizing role of its 2'-hydroxyl groups, Li discusses how proteins recognize different RNA folds, which include duplex RNA. With the fundamentals laid out, discussion turns to more specialized examples taken from important aspects of nucleic acid metabolism. Schroeder discusses how proteins chaperone RNA by rearranging its structure into a functional form. Berger and Dong discuss how topoisomerases alter the topology of DNA and relieve the superhelical tension introduced by other processes such as replication and transcription. Dyda and Hickman show how DNA transposes mediate genetic mobility and Van Duyne discusses how site-specific recombinases "cut" and "paste" DNA. Horton presents a comprehensive review of the structural families and chemical mechanisms of DNA nucleases, whereas Li in her discussion of RNA-protein recognition also covers RNA nucleases. Lastly, Ferre-D'Amare shows how proteins recognize and modify RNA transcripts at specific sites. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject DNA-protein interactions.
DNA-protein interactions.
RNA-protein interactions.
RNA-protein interactions.
Genre/Form Electronic books.
Added Author Rice, Phoebe A.
Correll, Carl C.
Other Form: Print version: 9780854042722 0854042725 (OCoLC)212431625
ISBN 9781847558268 (electronic book)
1847558267 (electronic book)
0854042725 (hardback)
9780854042722 (hardback)
1847558267
9780854042722