| Description |
1 online resource (1 PDF file (x, 65 pages)) : illustrations. |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
Consensus study report
|
|
Consensus study report.
|
| Note |
"A consensus study report of the National Academies of Sciences, Engineering, and Medicine." |
| Bibliography |
Includes bibliographical references. |
| Summary |
Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification. |
| Funding |
This activity was supported by a contract (W81K04-16-D-0036/W81K0418F0055) between the National Academy of Sciences and the U.S. Department of Defense. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. |
| Contents |
Introduction -- Approaches to developing exposure values -- Scoping and problem formulation -- Hazard identification -- Quantitative dose-response assessment and derivation of occuational exposure levels -- Conclusions -- Appendixes |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
United States. Department of Defense.
|
|
United States. Department of Defense. |
|
Trichloroethylene -- Threshold limit values.
|
|
Trichloroethylene. |
|
Solvents -- Threshold limit values.
|
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Solvents. |
|
Biological exposure indices (Industrial toxicology)
|
|
Biological exposure indices (Industrial toxicology) |
|
United States. |
| Genre/Form |
Review.
|
| Note |
Review of Department of Defense's approach to deriving an occupational exposure level for trichloroethylene |
| Other Form: |
Print version: National Academies of Sciences, Engineering, and Medicine (U.S.). Committee to Review DOD's Approach to Deriving an Occupational Exposure Limit for TCE. Review of DOD's approach to deriving an occupational exposure level for trichloroethylene. Washington, DC : The National Academies Press, [2019] 0309499240 9780309499248 (OCoLC)1132419167 |
| ISBN |
9780309499248 |
|
0309499240 |
|
9780309499279 (electronic book) |
|
0309499275 (electronic book) |
|
9780309499255 |
|
0309499259 |
|
