Issues in risk assessment / Committee on Risk Assessment Methodology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.
Use of the maximum tolerated dose in animal bioassays for carcinogenicity -- Introduction -- Correlations between carcinogenic potency and other measures of toxicity -- Advantages and disadvantages of bioassays that use the MTD -- Options considered -- Conclusions and recommendations -- Two-stage model of carcinogenesis -- Issues in risk assessment -- Paradigm for ecological risk assessment -- Introduction -- Scope of ecological risk assessment -- Revision of 1983 framework to incorporate ecological risk assessment -- Key scientific problems limiting application of ecological risk assessment -- Conclusions -- Recommendations.
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