| Description |
1 online resource (x, 123 pages) : illustrations. |
| Physical Medium |
monochrome |
| Description |
text file |
| Series |
Issues in environmental science and technology,
1350-7583 ;
23
|
|
Issues in environmental science and technology ; 23.
1350-7583
|
| Contents |
GENERAL OVERVIEW OF THE SAFETY EVALUATION OF CHEMICALS / Paul Illing -- Introduction -- Legislation and regulatory requirements -- The regulatory paradigm -- The interface between toxicology and risk assessment -- Interpreting toxicology -- Conclusions -- References -- INTERNATIONAL VALIDATION AND BARRIERS TO THE VALIDATION OF ALTERNATIVE TESTS / Michael Balls -- Introduction -- Background to the validation process -- The validation process -- Problems being encountered in implementing the validation process -- The need for an invalidation process -- Concluding remarks -- References -- IN VITRO TESTING FOR ENDOCRINE DISRUPTORS / Robert D. Combes -- Introduction -- In silico approaches -- In vitro tests for EDs -- Discussion -- Conclusions -- Acknowledgment -- References -- iNTELLIGENT APPROACHES TO SAFETY EVALUATION / Derek J. Knight -- Introduction -- Hazardous properties assessment -- Risk assessment -- Existing studies and literature data -- Surrogate data: calculation, read across and SAR/QSAR -- Alternatives to animal toxicology studies -- Data waivers -- Expert reports and weight of evidence -- Preliminary risk assessments -- EU Registration, Evaluation and Registration Scheme (REACH) -- Data for REACH -- Regulatory planning & liaison with the regulators -- Common themes -- Acknowledgments -- References -- ALTERNATIVE TESTS AND THE 7TH AMENDMENT TO THE COSMETICS DIRECTIVE / Carl Westmoreland -- Introduction -- Overview of current approaches to risk assessment for cosmetics -- 7th Amendment to the EU Cosmetics Directive (76/768/EEC) -- Status of alternative tests -- Endpoints where risk assessment for cosmetics can be achieved without using animal data -- Endpoints where risk assessment for cosmetics cannot currently be achieved without using animal data -- New approaches to risk assessment without animals -- Acknowledgments -- Abbreviations -- References. |
| Bibliography |
Includes bibliographical references and index. |
| Summary |
This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity. Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Alternative toxicity testing.
|
|
Alternative toxicity testing. |
|
Animal experimentation.
|
|
Animal experimentation. |
| Genre/Form |
Electronic books.
|
| Added Author |
Hester, R. E. (Ronald E.)
|
|
Harrison, Roy M., 1948-
|
| Other Form: |
Print version: Alternatives to animal testing. Cambridge : Royal Society of Chemistry, ©2006 9780854042111 (DLC) 2006494634 (OCoLC)70885520 |
| ISBN |
9781847552457 (electronic book) |
|
1847552455 (electronic book) |
| Standard No. |
10.1039/9781847552457 |
|
