| Description |
1 online resource (xviii, 263 pages) : illustrations |
| Physical Medium |
polychrome |
| Description |
text file |
| Summary |
Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition. |
| Contents |
M.S. Albert, Normal and Abnormal Memory: Aging and Alzheimer's Disease. -- S.J. Lupien and M.J. Meaney, Stress, Glucocorticoids, and Hippocampal Aging in Rat and Human. -- C.A. Barnes, Spatial Cognition and Functional Alterations of Aged Rat Hippocampus. -- A.J. Silva, K.P. Giese, and P.W. Frankland, Identification of Molecular and Cellular Mechanisms of Learning and Memory: The Impact of Gene Targeting. -- B.T. Hyman and T. Gomez-Isla, Normal Aging and Alzheimer's Disease. -- J.-P. Julien, Transgenic Mouse Models with Neurofilament-Induced Pathologies. -- P.C. Wong, D.R. Borchelt, M.K. Lee, G. Thinakaran, S.S. Sisodia, and D.L. Price, Transgenic Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease. -- G.M. Martin, Toward a Genetic Analysis of Unusually Successful Neural Aging. -- R.E. Tanzi, The Role of the Presenilins in Alzheimer's Disease. -- J.Q. Trojanowski, J.E. Galvin, M.L. Schmidt, P.-H. Tu, T. Iwatsubo, and V.M.-Y. Lee, Mechanisms of Neuron Death in Neurodegenerative Diseases of the Elderly: Role of the Lewy Body. -- S.-H. Yen, P. Nacharaju, L.-W. Ko, A. Kenessey, and W.-K. Liu, Microtubule-Associated Protein Tau: Biochemical Modifications, Degradation and Alzheimer's Disease. -- K.S. Kosik, C. Ho, U. Liyange, C. Lemere, M. Medina, and J. Zhou, A Novel Gene in the Armadillo Family Interacts with Presenilin 1. -- R. Quirion, D. Auld, U. Beffert, J. Poirier, and S. Kar, Putative Links Between Some of the Key Pathological Features of the Alzheimer's Brain. -- A. LeBlanc, Unraveling the Controversy of Human Prion Protein Diseases. -- E. Wang, Translational Control, Apoptosis, and the Aging Brain. -- H.M. Schipper, Astrocyte Senescence and the Pathogenesis of Parkinson's Disease. -- Index. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Normal and abnormal memory: aging and Alzheimer's disease -- Stress, glucocorticoids, and hippocampal aging in rat and human -- Spatial cognition and functional alterations of aged rat hippocampus -- Identification of molecular and cellular mechanisms of learning and memory: the impact of gene targeting -- Normal aging and Alzheimer's disease -- Transgenic mouse models with neurofilament-induced pathologies -- Transgenic models of amyotrophic lateral sclerosis and Alzheimer's disease -- Toward a genetic analysis of unusually successful neural aging -- The role of the presenilins in Alzheimer's disease -- Mechanisms of neuron death in neurodegenerative diseases of the elderly: role of the Lewy body -- Microtubule-associated protein tau: biochemical modifications, degradation, and Alzheimer's disease -- A novel gene in the armadillo family interacts with presenilin 1 -- Putative links between some of the key pathological features of the Alzheimer's brain -- Unraveling the controversy of human prion protein diseases -- Translational control, apoptosis, and the aging brain -- Astrocyte senescence and the pathogenesis of Parkinson's disease. |
| Access |
Use copy Restrictions unspecified MiAaHDL |
| Reproduction |
Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL |
| System Details |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
| Processing Action |
digitized 2010 HathiTrust Digital Library committed to preserve MiAaHDL |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Brain -- Aging.
|
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Brain -- Aging. |
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Alzheimer's disease -- Physiological aspects.
|
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Alzheimer's disease -- Physiological aspects. |
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Alzheimer's disease. |
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Aging. |
| Genre/Form |
Electronic books.
|
| Added Author |
Wang, E. (Eugenia), 1945-
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Snyder, D. Stephen.
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| Added Title |
Aging brain |
| Other Form: |
Print version: Handbook of the aging brain. San Diego : Academic Press, ©1998 0127346104 9780127346106 (DLC) 98084430 (OCoLC)39693287 |
| ISBN |
9780127346106 |
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0127346104 |
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9780080533223 (electronic book) |
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0080533221 (electronic book) |
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1281057142 |
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9781281057143 |
|
