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019 863088108|a897578461|a923289661
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049 RIDW
050 4 R856.A2|b.N487 2013
072 7 HEA|x039000|2bisacsh
072 7 MED|x014000|2bisacsh
072 7 MED|x022000|2bisacsh
072 7 MED|x112000|2bisacsh
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082 04 616.8/047|223
090 R856.A2|b.N487 2013
111 2 Neurodegeneration: Opportunities for Collaboration Across
Disease-Specific Research and Development Communities
(Workshop),|d(2012 :|cWashington, D.C.)|0https://
id.loc.gov/authorities/names/no2013144391
245 10 Neurodegeneration :|bexploring commonalities across
diseases : workshop summary /|cMiriam Davis and Clare
Stroud, rapporteurs ; Forum on Neuroscience and Nervous
System Disorders, Board on Health Sciences Policy,
Institute of Medicine of the National Academies.
264 1 Washington, D.C. :|bNational Academies Press,|c[2013]
264 4 |c©2013
300 1 online resource (106 pages) :|billustrations (chiefly
color)
336 text|btxt|2rdacontent
337 computer|bc|2rdamedia
338 online resource|bcr|2rdacarrier
347 text file|2rdaft
504 Includes bibliographical references.
505 0 Introduction -- Rationale for exploring commonalities
across neurodegenerative diseases -- Protein aggregation -
- Transmissibility -- Mitochondrial pathology -- Errors in
RNA -- Closing remarks.
520 "Neurodegeneration: Exploring Commonalities Across
Diseases is the summary of a workshop hosted by the
Institute of Medicine's (IOM's) Forum on Neuroscience and
Nervous System Disorders in Spring 2012 to explore
commonalities across neurodegenerative diseases such as
Alzheimer's disease, Parkinson's disease, amyotrophic
lateral sclerosis (ALS), and frontotemporal dementia
(FTD). Participants from academia; pharmaceutical and
biotechnology industries; government agencies such as the
National Institutes of Health and the U.S. Department of
Veterans Affairs (VA); patient advocacy groups; and
private foundations presented and identified potential
opportunities for collaboration across the respective
research and development communities. This report
identifies and discusses commonalities related to genetic
and cellular mechanisms, identifies areas of fundamental
science needed to facilitate therapeutics development, and
explores areas of potential collaboration among the
respective research communities. Neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease,
ALS, and FTD, are becoming increasingly prevalent in the
United States due to an aging population. Implications are
grave for quality of life and health care costs. Research
on neurodegenerative diseases has expanded greatly over
the past four decades. Nevertheless, fundamental questions
remain about the biology of these diseases, and further
insights into the mechanisms of these diseases would help
to inform the development of effective means to prevent
and to efficiently treat them. Recent findings have
revealed certain commonalities in genetic and cellular
mechanisms across neurodegenerative diseases. These
findings suggest that it might be valuable - at least in
some cases - to change the traditional way of studying
these diseases by no longer seeing each as an independent
entity, but rather as clinical variants of common cellular
and molecular biological defects. This approach could help
enhance basic scientific understanding of
neurodegenerative disease, and could help with the
development of biomarkers and new therapeutics."
588 0 Online resource; title from resource home page (National
Academies Press, viewed December 31, 2013).
590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic
Collection - North America
650 0 Nervous system|xDegeneration|0https://id.loc.gov/
authorities/subjects/sh85090923|vCongresses.|0https://
id.loc.gov/authorities/subjects/sh99001533
650 0 Biology|xResearch.|0https://id.loc.gov/authorities/
subjects/sh89006496
650 7 Nervous system|xDegeneration.|2fast|0https://
id.worldcat.org/fast/1036090
650 7 Biology|xResearch.|2fast|0https://id.worldcat.org/fast/
832448
650 12 Neurodegenerative Diseases.|0https://id.nlm.nih.gov/mesh/
D019636
650 12 Biomedical Research.|0https://id.nlm.nih.gov/mesh/D035843
650 22 Research Design.|0https://id.nlm.nih.gov/mesh/D012107
655 2 Congress.|0https://id.nlm.nih.gov/mesh/D016423
655 4 Electronic books.
655 7 Conference papers and proceedings.|2fast|0https://
id.worldcat.org/fast/1423772
655 7 Conference papers and proceedings.|2lcgft|0https://
id.loc.gov/authorities/genreForms/gf2014026068
700 1 Davis, Miriam|c(Medical writer),|0https://id.loc.gov/
authorities/names/no2008006254|erapporteur.
700 1 Stroud, Clare,|0https://id.loc.gov/authorities/names/
no2010012744|erapporteur.
710 2 Institute of Medicine (U.S.).|bForum on Neuroscience and
Nervous System Disorders,|0https://id.loc.gov/authorities/
names/no2008032406|esponsoring body.
776 08 |iPrint version:|aNeurodegeneration: Opportunities for
Collaboration Across Disease-Specific Research and
Development Communities (Workshop), (2012 : Washington,
D.C.).|tNeurodegeneration.|dWashington, D.C. : National
Academies Press, [2013]|z9780309285674|w(OCoLC)868671560
856 40 |uhttps://rider.idm.oclc.org/login?url=http://
search.ebscohost.com/login.aspx?direct=true&scope=site&
db=nlebk&AN=867711|zOnline eBook. Access restricted to
current Rider University students, faculty, and staff.
856 42 |3Instructions for reading/downloading this eBook|uhttp://
guides.rider.edu/ebooks/ebsco
901 MARCIVE 20231220
948 |d20160607|cEBSCO|tebscoebooksacademic|lridw
994 92|bRID
