| Description |
1 online resource (1 PDF file (xi, 97 pages)) : illustrations |
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text file |
| Note |
Title from PDF title page. |
| Bibliography |
Includes bibliographical references. |
| Summary |
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. |
| Funding |
This project was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; CeNeRx Biopharma; the Department of Health and Human Services' National Institutes of Health (NIH, Contract No. N01-OD-4-2139) through the National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; Department of Veterans Affairs; Eli Lilly and Company; Fast Forward, LLC; Foundation for the National Institutes of Health; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson's Research; the National Science Foundation (Contract No. OIA-0753701); One Mind for Research; Pfizer Inc.; the Society for Neuroscience; and Wellcome Trust. |
| Contents |
Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Nervous System Diseases -- drug therapy. |
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Translational Research, Biomedical. |
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Models, Animal. |
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Drug Evaluation, Preclinical. |
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Clinical Trials as Topic. |
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Research Design. |
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Nervous system -- Diseases -- Animal models.
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Nervous system -- Diseases -- Animal models. |
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Nervous system -- Diseases. |
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Animal models in research.
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Animal models in research. |
| Genre/Form |
Congress.
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Electronic books.
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Conference papers and proceedings.
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Conference papers and proceedings.
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| Added Author |
Wizemann, Theresa M., author.
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Altevogt, Bruce M., author.
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Institute of Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders, sponsoring body.
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Workshop "Improving Translation of Animal Models for Nervous System Disorders" (2012 : Institute of Medicine (U.S.))
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| Other Form: |
Print version: Improving the utility and translation of animal models for nervous system disorders. Washington, D.C. : National Academies Press, [2013] 9780309266338 (DLC) 2013427677 (OCoLC)846679526 |
| ISBN |
9780309266338 |
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0309266335 |
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9780309266345 |
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0309266343 |
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