| Description |
1 online resource (1 PDF file (xii, 50 pages)) : illustrations |
| Bibliography |
Includes bibliographical references. |
| Summary |
Accumulating evidence gathered over the past three decades has demonstrated a biological basis for differences between men and women with respect to clinical features and treatment responses to several neuropsychiatric, neurodevelopmental, and neurodegenerative disorders. Dramatic sex differences have also been identified in the brain transcriptomes of individuals with multiple brain disorders, including depression, posttraumatic stress disorder, and autism. The brain transcriptome includes all of the messenger RNA as well as the non-protein-coding RNA molecules expressed in brain tissue and thus represents gene activity. To explore these sex-based transcriptomic differences further, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop on September 23, 2020, titled Sex Differences in Brain Disorders: Emerging Transcriptomic Evidence and Implications for Therapeutic Development. The workshop brought together a broad spectrum of stakeholders to share cutting-edge emerging evidence, discuss challenges, and identify future opportunities and potential directions. This publication summarizes the presentation and discussion of the workshop. |
| Funding |
This activity was supported by contracts between the National Academy of Sciences and Alzheimer's Association; Cohen Veterans Bioscience; Department of Health and Human Services' Food and Drug Administration (5R13FD005362-05 and 1R13FD005362-06) and National Institutes of Health (NIH) (75N98019F00469 [Under Master Base HHSN263201800029I]) through the National Center for Complementary and Integrative Health, National Eye Institute, National Institute of Environmental Health Sciences, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, NIH Blueprint for Neuroscience Research, and NIH BRAIN Initiative; Department of Veterans Affairs (36C24E20C0009); Eisai Inc.; Eli Lilly and Company; Foundation for the National Institutes of Health; Gatsby Charitable Foundation; Janssen Research & Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson's Research; National Multiple Sclerosis Society; National Science Foundation (DBI-1839674); One Mind; Sanofi; Society for Neuroscience; Takeda Pharmaceuticals International, Inc.; and Wellcome Trust. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Sex differences.
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Sex differences (Psychology)
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Mental illness -- Sex differences.
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Human behavior -- Physiological aspects.
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Sex factors in disease.
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Sex factors in disease. |
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Sex differences. |
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Sex differences (Psychology) |
| Genre/Form |
Conference papers and proceedings.
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Congress
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Conference papers and proceedings.
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| Added Author |
Norris, Sheena M. Posey, rapporteur.
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Stroud, Clare, rapporteur.
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National Academies of Sciences, Engineering, and Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders. issuing body.
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Sex Differences in Brain Disorders: Emerging Transcriptomic Evidence and Implications for Therapeutic Development (Workshop) (2020 : Online)
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| Other Form: |
Print version: National Academies of Sciences, Engineering, and Medicine Sex Differences in Brain Disorders Washington, D.C. : National Academies Press,c2021 9780309265102 |
| ISBN |
9780309265119 |
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0309265118 |
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9780309265232 (electronic bk.) |
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0309265231 (electronic bk.) |
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9780309265102 |
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030926510X |
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