| Description |
1 online resource (xii, 396 pages) : illustrations |
| Physical Medium |
polychrome |
| Description |
text file |
| Note |
Originally published in: Philosophical transactions of the Royal Society series B. 2000. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Introduction. Questions about the behaviour of bacterial pathogens in vivo / H. Smith -- DNA topology and adaptation of Salmonella typhimurium to an intracellular environment / D.G. Marshall [and others] -- New methods for studying bacterial behaviour in vivo. The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies / D.J. Philpott, J.D. Edgeworth and P.J. Sansonetti -- Detection and analysis of gene expression during infection by in vivo expression technology / D.S. Merrell and A. Camilli -- Measurement of bacterial gene expression in vivo / J. Hautefort and J.C.D. Hinton -- Identification and analysis of bacterial virulence genes in vivo / K.E. Unsworth and D.W. Holden -- Salmonella interactions with host cells: in vitro to in vivo / B.B. Finlay and J.H. Brumell -- Impact of the new methods. In vivo gene expression and the adaptive response: from pathogenesis to vaccines and antimicrobials / D.M. Heithoff [and others] -- Challenge of investigating biologically relevant functions of virulence factors in bacterial pathogens / R. Moxon and C. Tang -- Virulence gene regulation inside and outside / V.J. DiRita [and others] -- Evidence for operation in vivo of aspects of pathogenicity revealed by recent work in vitro: potential use of new methods. Quorum sensing and the population-dependent control of virulence / P. Williams [and others] -- Type III secretion: a bacterial device for close combat with cells of their eukaryotic host / G.R. Cornelis -- Evolution of microbial pathogens / J. Morschhäuser [and others] -- The immune responses to bacterial antigens encountered in vivo at mucosal surfaces / G. Dougan [and others]. |
| Summary |
Pathogenic bacteria have unique biological properties, which enable them to invade a host and cause sickness. The molecular bases of these biological properties are the determinants of pathogenicity, and the research objectives are to recognize them, identify them chemically and relate their structure to function. Most of our present knowledge comes from studies with cultures in vitro. However, there is a rising interest in bacterial behaviour in the infected host and new methods have been developed for studying it. This book describes those methods and shows how they, and a recent surge in conventional studies, are shedding light on the activities of bacterial pathogens in vivo. It discusses bacterial and host factors that operate in vivo to cause illness, showing how phenomena recognized in vitro relate to behaviour in vivo and, if evidence of relevance is not available now, indicating how it might be obtained. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Virulence (Microbiology) -- Congresses.
|
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Virulence (Microbiology) |
|
Bacterial diseases -- Congresses.
|
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Bacterial diseases. |
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Pathogenic bacteria -- Congresses.
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Pathogenic bacteria. |
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Host-bacteria relationships -- Research -- Methodology -- Congresses.
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Host-bacteria relationships. |
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Research. |
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Methodology. |
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Molecular microbiology -- Congresses.
|
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Molecular microbiology. |
|
Bacteria. |
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Molecular Biology. |
|
Virulence. |
| Genre/Form |
Congress.
|
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Electronic books.
|
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Conference papers and proceedings.
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Conference papers and proceedings.
|
| Added Author |
Smith, Harry, 1921-2011.
|
|
Royal Society (Great Britain)
|
| Other Form: |
Print version: Activities of bacterial pathogens in vivo. London : Imperial College Press, 2001 1860942725 9781860942723 (DLC) 2002277434 (OCoLC)49240230 |
| ISBN |
9781848161610 (electronic book) |
|
1848161611 (electronic book) |
|
9781860942723 |
|
1860942725 |
|
