| Description |
1 online resource (212 pages). |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
Anti-Angiogenesis Drug Discovery and Development Ser.
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Anti-Angiogenesis Drug Discovery and Development Ser.
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| Note |
Description based upon print version of record. |
| Summary |
The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery scien. |
| Contents |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Therapeutic Targeting of the Tumor Vasculature: Past, Present and Future -- Peace Mabeta1,*, Mike Sathekge2 and Vanessa Steenkamp3 -- INTRODUCTION -- ANGIOGENESIS IN TUMOR PROGRESSION -- The Tumor Vasculature -- Importance of Vascular Endothelial Growth Factor Signaling in Cancer -- Therapeutic Targeting of Vascular Endothelial Growth Factor -- BEYOND BEVACIZUMAB -- Ramucirumab -- Apatinib -- Effectiveness of Anti-VEGF Versus Anti-VEGFR Therapy |
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DEVELOPMENT OF RESISTANCE TO VEGF/VEGFR-2 TARGETING DRUGS -- Platelet-Derived Growth Factor Pathway -- Fibroblast Growth Factor Signaling in Anti-Cancer Therapy -- Angiopoietin-Tie Pathway in Therapeutic Anti-Angiogenesis -- THERAPEUTIC TARGETING OF MULTIPLE ANGIOGENIC PATHWAYS -- Multi-Targeting Tyrosine Kinase Inhibitors -- Sorafenib -- Sunitinib -- Axitinib -- Pazopanib -- Nintedanib -- Multi-Targeting Versus Mono-Targeting AIs -- FUSION PEPTIDES AND DECOY RECEPTORS -- Aflibercept -- Abexinostat and Panobinostat Attenuate Hypoxia -- IMMUNE CELLS AND THE EFFECTIVENESS OF ANGIOGENESIS INHIBITORS |
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OVERCOMING INFLAMMATION -- ANGIOGENESIS INHIBITORS AND IMMUNOTHERAPY -- Normalization of the Tumor Vasculature -- FUTURE PERSPECTIVE -- IMAGING BIOMARKERS IN ANGIOGENESIS -- CONCLUSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Anti-angiogenic Mechanism, Biochemical Factors' Roles, Therapeutic Agents, and Under Clinical Trial Drugs for Breast and Prostate Cancers -- Varsha M. Singh1, Shilpa J. Newati1, Mohammad Yusuf2, Alexandre Bridoux3,4, Salman A. A. Mohammed5, Naseem Akhtar6 and Riaz A. Khan1,5,* -- INTRODUCTION: THE ANGIOGENESIS AND CANCERS |
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ANGIOGENIC BIOMECHANISMS: NORMAL VERSUS TUMOR-INDUCED -- Tumor Vasculature -- Operational Signaling Pathways in Tumor -- Angiogenic Promoters and their Involvement in Breast Cancer -- Angiogenin -- Vascular Endothelial Growth Factors (VEGFs) -- Interleukins -- Fibroblast Growth Factors (FGF) -- Matrix MetalloProteinases (MMPs) and Matrix Remodeling -- Angiopoietins -- Roles of Integrins in Tumorigenesis -- ANGIOGENIC INHIBITORS -- Interferons -- Endostatin -- Angiostatin -- Thrombospondin -- Decorin -- Commercially Aailable Angiogenic Inhibitors |
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CLINICAL TRIALS TOWARDS ANTI-ANGIOGENIC DRUGS DEVELOPMENT -- Bevacizumab -- Cilengitide -- Aflibercept -- Ramucirumab -- Sorafenib -- Sunitinib -- Vandetanib -- Axitinib -- Pazopanib -- Drugs Approved to Treat Breast Cancers -- RELATIONSHIP BETWEEN INFLAMMATION, ANGIOGENESIS, AND COAGULATION IN PROSTATE CANCERS -- ANGIOGENESIS, THROMBOSIS AND INFLAMMATION MEDIATORS' CROSSTALK -- 6.1. Angiogenesis and Inflammation Mediators' Crosstalk -- Angiogenic Capability of Tumors and Thromboembolic Crosstalk -- CLINICAL TRIALS FOR ANTI-ANGIOGENIC PROSTATE CANCER DRUG DEVELOPMENT |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Neovascularization inhibitors.
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Neovascularization inhibitors. |
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Neovascularization.
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Neovascularization. |
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Drug development.
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Drug development. |
| Genre/Form |
Electronic books.
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| Added Author |
Choudhary, Muhammad Iqbal.
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| Other Form: |
Print version: Atta-ur-Rahman Anti-Angiogenesis Drug Discovery and Development: Volume 5 Singapore : Bentham Science Publishers,c2020 9789811432866 |
| ISBN |
9811432872 |
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9789811432873 (electronic book) |
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