| Description |
1 online resource (245 pages) |
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text file |
| Series |
Anti-Obesity Drug Discovery and Development.
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| Contents |
PREFACE; List of Contributors ; Current Status of Medical Therapy and New Targets for Anti-Obesity Drug Development ; Chihiro Okuma, Yukihito Ishii and Takeshi Ohta*; INTRODUCTION; Approved Drugs; Phentermine; Mazindol; Fenfluramine/Dexfenfluramine; Orlistat; Shibutramine; Rimonabant; Qsymia; BELVIQ (Lorcaserin); Contrave; New Drug Targets (Table 3); Late Phase Clinical Development; Early Phase Clinical Stage Development or Pre-Clinical Development Stage Late Phase Clinical Development; Future Prospects; Obesity Animal Models; ob/ob Mouse; db/db Mouse; KK-Ay Mouse; TSOD Mouse. |
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SDT fatty RatZF Rat; ZDF Rat; cp/cp Rat; WBN/Kob fatty Rat; DIO Models; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Unravelling Potential Anorexigen Effects of Nesfatin-1: How Homeostatic Mechanisms Help Balance Excess Calories ; Carmine Finelli*; INTRODUCTION; Nesfatin-1/NUCB-2 and Anorexigenic Effect; The Oxytocin Pathway in Nesfatin-1's Inhibitory Effect on Food Intake; Nesfatin-1 and CRF; Nesfatin-1 and Anti-Obesity Treatment; Nesfatin-1 and Food Behaviour Control; Nesfatin-1 and Signaling Pathway; Nesfatin-1 and Eating Disorders; CONCLUSIVE REMARKS; CONFLICT OF INTEREST. |
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ACKNOWLEDGEMENTSABBREVIATIONS; REFERENCES; Proteomics in the Characterization of New Target Therapies in Pediatric Obesity Treatment ; Gillian E. Walker1,*, Marilisa De Feudis1, Marta Roccio1, Gianni Bona2 and Flavia Prodam2; INTRODUCTION; CHILDHOOD OBESITY: PATHOLOGICAL BASIS; Genetic Considerations for Childhood Obesity; Energy Homeostasis Dysregulation; Pathophysiology of Adipose Tissue; PROTEOMICS; Gel Based Methods; Non Gel Based Methods: Mass Spectrometry (MS); Chips; Challenges; PROTEOMIC STUDIES OF ADIPOSE TISSUE; WAT Depots; WAT Secretome; BAT; Stromal-Vascular Fraction (SVF). |
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PROTEOMIC STUDIES IN ADIPOCYTES: STEM CELLS AND CELL LINESAdipogenesis: Adipo-proteomics; Murine 3T3-L1 Preadipocytes; Adipocyte-Derived Stem Cells (ASCs); Adipocyte Secretome; Post-Translational Modifications (PTMs); PROTEOMIC PROFILING: TISSUES AND CIRCULATION; Fetal Programming: Tissue-Specific Biomarkers; Circulating Biomarkers; Urine Biomarkers; OUTLOOKS; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; ABBREVIATIONS; REFERENCES. |
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Relationship Between Hormonal Milieu and Oxidative Stress in Childhood Obesity: A Physiopathological Basis for Antioxidant Treatment and Prevention of Cardiovascular Risk Antonio Mancini*, Francesco Leo, Chantal Di Segni, Sebastiano Raimondo and Aurora Natalia Rossodivita; INTRODUCTION; OBESITY AND OXIDATIVE STRESS; Hormones and Inflammatory Molecules Produced by or Related to Adipose Tissue; Oxidative Stress in Childhood Obesity; HORMONAL REGULATION OF ANTIOXIDANT SYSTEMS AND THEIR DERANGEMENT IN CHILDHOOD OBESITY; Growth Hormone (GH); Thyroid; Adrenal Glands; Gonads. |
| Note |
Adipose tissue (Leptin and Kisspeptin). |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Appetite depressants.
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Appetite depressants. |
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Obesity.
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Obesity. |
| Genre/Form |
Electronic books.
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| Added Author |
Rahman, Atta-ur-
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Choudhary, Muhammad Iqbal.
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| Other Form: |
Print version: Rahman, Atta-ur. Anti-Obesity Drug Discovery and Development Volume 3. Sharjah : Bentham Science Publishers, ©2017 9781681081885 |
| ISBN |
9781681081878 (electronic book) |
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1681081873 (electronic book) |
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