Description |
1 online resource. |
Physical Medium |
polychrome |
Description |
text file |
Series |
Chemical biology ; 18
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Chemical biology series ; no. 18.
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Summary |
From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics with an integrative approach to understanding the role of nitrogen in its many biologic roles. Authored by a renowned scientist and educator, this book is ideal for researchers in chemical biology and nitrogen metabolism and will be of particular interest to advanced students and postgraduates in biochemistry and chemical biology. |
Bibliography |
Includes bibliographical references and index. |
Contents |
Intro -- Half Title -- Chemical Biology -- Title -- Copyright -- Preface -- Dedication -- Contents -- Section I -- Chapter 1 Introduction to Nitrogen Chemical Biology -- 1.1 Nitrogen Chemical Biology -- 1.2 Properties of Atomic and Molecular Nitrogen Relevant to Biology -- 1.3 Accessible Nitrogen Oxidation States in Biology -- 1.4 Nitrogen Biogeochemical Cycling 1 -- 1.5 Inorganic Nitrogen Metabolism uses the Eight-electron Nitrogen Redox Traverse in Either Direction -- 1.6 Nitrogen Biogeochemical Cycling 2 -- 1.7 Crossover to Organic Nitrogen Chemical Biology by Enzymatic Capture of Ammonia |
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1.8 What Kinds of Nitrogen Molecules and Functional Groups Operate in Metabolism? -- 1.9 Nitrogen Heterocycles as Central Structural and Catalytic Groups -- 1.10 One-electron vs. Two-electron Nitrogen Redox Enzymology -- 1.11 Nitrogen Proteomics: Catalysis vs. Posttranslational Modifications -- 1.12 Overview -- References -- Section II -- Chapter 2 Inorganic Nitrogen Biochemistry and Dinitrogen Reduction to Ammonia by Nitrogenase -- 2.1 Introduction to N2, NH3 and NO3− -- 2.2 Nitrification, Denitrification and Reductive Assimilation |
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2.3 N2 to NH3: Biological Fixation of Dinitrogen by Bacterial Nitrogenases -- 2.3.1 Alternative to Nitrogenase -- 2.3.2 The Haber-Bosch Industrial Process -- 2.4 Nitrogen-fixing Bacteria -- 2.4.1 Nitrogenase Structures and Reaction Stoichiometries -- 2.4.2 Nitrogenase Redox Cofactor Inventories -- 2.4.3 Thoughts on Nitrogenase Mechanisms -- 2.5 Nitrogen Hydride Biochemistry -- References -- Chapter 3 Ammonia Oxidation: Nitrification vs. Anammox -- 3.1 Nitrification: Ammonia Oxidation to Nitrate -- 3.1.1 Ammonia Oxidase -- 3.1.2 Hydroxylamine Oxidoreductase -- 3.1.3 Nitric Oxide Oxidase |
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3.1.4 Nitrite Oxidase (in Nitrite Oxidizing Bacteria) -- 3.1.5 Overview: Nitrification: Ammonia to Nitrate Oxidative Pathway -- 3.2 Anammox by the Anaerobic Bacterial Phylum Plantomycetes -- 3.2.1 Hydrazine Synthase -- 3.2.2 Hydrazine Dehydrogenase -- 3.3 Ammonification: Degradative Conversion of Organic Nitrogen Metabolites to NH3 -- References -- Chapter 4 Nitrate Ion Reductive Metabolism: Bifurcation Between Five-electron or Eight-electron Reductions -- 4.1 Two Modes of Biological Reduction of Nitrate Ions -- 4.2 Nitrate Reduction: NO3− to NH3 for Assimilation: Eight-electron Reduction |
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4.2.1 Nitrate Reductases -- 4.2.2 Nitrite Reductases -- 4.3 Denitrification: two NO3− to N2, Net Ten-electron Reduction -- 4.3.1 Denitrifying Nitrate Reductase -- 4.3.2 Denitrifying Nitrite Reductases: One-electron Reductions -- 4.3.3 Nitric Oxide Reductase in Denitrifying Bacteria -- 4.3.4 Nitrous Oxide Reductase -- 4.4 Overview of the Metallocenter Inventory in the Denitrification Pathway -- References -- Chapter 5 Chemical Strategies Underlying the Biological Flux of Inorganic Nitrogen Species -- 5.1 Traversing the Full Range of Nitrogen Redox States |
Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
Subject |
Nitrogen.
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Nitrogen. |
Genre/Form |
Electronic books.
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Other Form: |
Print version: WALSH, CHRISTOPHER T. CHEMICAL BIOLOGY OF NITROGEN. Cambridge : Royal Society of Chemistry, 2021 9781839163920 (OCoLC)1223071638 |
ISBN |
9781839164330 (electronic book) |
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1839164336 (electronic book) |
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9781839164347 (electronic book) |
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1839164344 (electronic book) |
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9781839163920 |
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1839163925 |
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