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Title Implantable technologies : peptides and small molecules drug delivery / edited by Ved Srivastava.

Publication Info. Cambridge : Royal Society of Chemistry, 2021.

Item Status

Description 1 online resource.
text file
Series Drug development and pharmaceutical science
Drug development and pharmaceutical science.
Contents Intro -- Half Title -- Series Title -- Title -- Copyright -- Foreword -- Preface -- Editor Biography -- Contents -- Chapter 1 Status of Implantable and Long-acting Injectable Technologies 1 -- 1.1 Introduction -- 1.2 Implantable Minipumps for Research and Preclinical Studies -- 1.2.1 The Alzet® Pump -- 1.2.2 iPRECIO® Microinfusion Pump -- 1.3 Implantable Minipump Devices in Commercial Application -- 1.4 Implantable Technologies Under Clinical Studies and Development -- 1.4.1 Medici Drug Delivery System™ -- 1.4.2 Microneedles Array Technology -- 1.4.3 Microchip Drug Delivery Devices
1.4.4 Biodegradable Injectable Drug Delivery System -- 1.5 Challenges with Implantable and Long-acting Injectable Technologies -- 1.6 Conclusion -- Acknowledgements -- References -- Chapter 2 Developing Complex Dosage Forms of Long-acting Biologics for the Eye: Current State, Challenges, and Opportunities 14 -- 2.1 Unmet Medical Needs for Long-acting Biologic Products for the Eye -- 2.1.1 Eye Diseases, Epidemiology, and Unmet Need for Long-acting Biologic Therapies -- 2.1.2 Ocular Drug-delivery Considerations
2.2 Success Criteria for Long-acting Ocular Biologic Products and Scientific Challenges -- 2.3 Complex Dosage Forms for the Eye: Current State and Trend -- 2.3.1 Introduction -- 2.3.2 Erodible Polymers -- 2.3.3 Implants -- 2.3.4 Nano- and Microparticles -- 2.3.5 In Situ-forming and Injectable Depots -- 2.3.6 Conjugation Approaches -- 2.3.7 Non-erodible Implantable Devices -- 2.4 Conclusions and Outlook -- Acknowledgements -- References -- Chapter 3 Monolithic Devices for Sustained Delivery of Protein Therapeutics for Ocular Disease 54 -- 3.1 Introduction
3.1.1 Posterior Segment Eye Diseases of Interest -- 3.1.2 Protein Therapeutics for Posterior Segment Eye Disease -- 3.2 Considerations for Sustained Delivery of Proteins and Biologics -- 3.2.1 Challenges in Ocular Drug Delivery -- 3.2.2 Animal Models for Preclinical Research -- 3.2.3 Non-biodegradable and Biodegradable Materials -- 3.3 Current Drug-delivery Implant Technology for Ocular Disease -- 3.3.1 Commercial Development -- 3.3.2 Ocular Drug-Delivery Implantable Technology in the Clinical Pipeline -- 3.3.3 Ocular Drug-delivery Implantable Technology in Preclinical Stages
3.4 Concluding Remarks -- Acknowledgements -- References -- Chapter 4 Sustained Delivery of Ocular Protein Therapeutics 76 -- 4.1 Introduction -- 4.2 Physicochemical Characteristics of the Vitreous Humour -- 4.3 Current Challenges in the Sustained Delivery of Ocular Therapeutics -- 4.3.1 Long-term Stability of Therapeutics -- 4.3.2 Limitations with Surrogate Vitreous Systems -- 4.4 Anti-VEGF Therapies -- 4.4.1 In Vitro Long-term Stability of Anti-VEGF Therapies -- 4.5 Development of the PDS -- 4.5.1 Overview -- 4.5.2 Preclinical Studies of the PDS -- 4.5.3 Clinical Studies on the PDS
Summary Implantable Technologies: Pepties and Biologic Drug Development is an ideal reference for any postgraduate or researcher interested in utilising implantable technologies and novel routes of drug administration.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Drug delivery devices.
Drug delivery devices.
Peptides -- Therapeutic use.
Peptides -- Therapeutic use.
Peptides.
Genre/Form Electronic books.
Other Form: Print version: 1839162228 9781839162220 (OCoLC)1242026543
ISBN 9781839165368 (electronic book)
1839165367 (electronic book)
9781839164958 (PDF ebook)
1839164956 (PDF ebook)
1839162228
9781839162220