Description |
1 online resource. |
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text file |
Series |
Drug development and pharmaceutical science
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Drug development and pharmaceutical science.
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Contents |
Intro -- Half Title -- Series Title -- Title -- Copyright -- Foreword -- Preface -- Editor Biography -- Contents -- Chapter 1 Status of Implantable and Long-acting Injectable Technologies 1 -- 1.1 Introduction -- 1.2 Implantable Minipumps for Research and Preclinical Studies -- 1.2.1 The Alzet® Pump -- 1.2.2 iPRECIO® Microinfusion Pump -- 1.3 Implantable Minipump Devices in Commercial Application -- 1.4 Implantable Technologies Under Clinical Studies and Development -- 1.4.1 Medici Drug Delivery System™ -- 1.4.2 Microneedles Array Technology -- 1.4.3 Microchip Drug Delivery Devices |
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1.4.4 Biodegradable Injectable Drug Delivery System -- 1.5 Challenges with Implantable and Long-acting Injectable Technologies -- 1.6 Conclusion -- Acknowledgements -- References -- Chapter 2 Developing Complex Dosage Forms of Long-acting Biologics for the Eye: Current State, Challenges, and Opportunities 14 -- 2.1 Unmet Medical Needs for Long-acting Biologic Products for the Eye -- 2.1.1 Eye Diseases, Epidemiology, and Unmet Need for Long-acting Biologic Therapies -- 2.1.2 Ocular Drug-delivery Considerations |
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2.2 Success Criteria for Long-acting Ocular Biologic Products and Scientific Challenges -- 2.3 Complex Dosage Forms for the Eye: Current State and Trend -- 2.3.1 Introduction -- 2.3.2 Erodible Polymers -- 2.3.3 Implants -- 2.3.4 Nano- and Microparticles -- 2.3.5 In Situ-forming and Injectable Depots -- 2.3.6 Conjugation Approaches -- 2.3.7 Non-erodible Implantable Devices -- 2.4 Conclusions and Outlook -- Acknowledgements -- References -- Chapter 3 Monolithic Devices for Sustained Delivery of Protein Therapeutics for Ocular Disease 54 -- 3.1 Introduction |
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3.1.1 Posterior Segment Eye Diseases of Interest -- 3.1.2 Protein Therapeutics for Posterior Segment Eye Disease -- 3.2 Considerations for Sustained Delivery of Proteins and Biologics -- 3.2.1 Challenges in Ocular Drug Delivery -- 3.2.2 Animal Models for Preclinical Research -- 3.2.3 Non-biodegradable and Biodegradable Materials -- 3.3 Current Drug-delivery Implant Technology for Ocular Disease -- 3.3.1 Commercial Development -- 3.3.2 Ocular Drug-Delivery Implantable Technology in the Clinical Pipeline -- 3.3.3 Ocular Drug-delivery Implantable Technology in Preclinical Stages |
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3.4 Concluding Remarks -- Acknowledgements -- References -- Chapter 4 Sustained Delivery of Ocular Protein Therapeutics 76 -- 4.1 Introduction -- 4.2 Physicochemical Characteristics of the Vitreous Humour -- 4.3 Current Challenges in the Sustained Delivery of Ocular Therapeutics -- 4.3.1 Long-term Stability of Therapeutics -- 4.3.2 Limitations with Surrogate Vitreous Systems -- 4.4 Anti-VEGF Therapies -- 4.4.1 In Vitro Long-term Stability of Anti-VEGF Therapies -- 4.5 Development of the PDS -- 4.5.1 Overview -- 4.5.2 Preclinical Studies of the PDS -- 4.5.3 Clinical Studies on the PDS |
Summary |
Implantable Technologies: Pepties and Biologic Drug Development is an ideal reference for any postgraduate or researcher interested in utilising implantable technologies and novel routes of drug administration. |
Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
Subject |
Drug delivery devices.
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Drug delivery devices. |
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Peptides -- Therapeutic use.
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Peptides -- Therapeutic use. |
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Peptides. |
Genre/Form |
Electronic books.
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Other Form: |
Print version: 1839162228 9781839162220 (OCoLC)1242026543 |
ISBN |
9781839165368 (electronic book) |
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1839165367 (electronic book) |
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9781839164958 (PDF ebook) |
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1839164956 (PDF ebook) |
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1839162228 |
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9781839162220 |
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