| Description |
1 online resource (xviii, 285 pages) : illustrations (some color). |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
Practical approach series ; 207
|
|
Practical approach series ; 207.
|
| Bibliography |
Includes bibliographical references and index. |
| Summary |
The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Steroid hormones -- Receptors.
|
|
Steroid hormones -- Receptors. |
|
Nuclear receptors (Biochemistry)
|
|
Nuclear receptors (Biochemistry) |
|
Transcription factors.
|
|
Transcription factors. |
|
Receptors, Cytoplasmic and Nuclear. |
|
Transcription Factors. |
|
Receptors, Steroid. |
| Genre/Form |
Laboratory Manual.
|
|
Electronic books.
|
| Added Author |
Picard, Didier.
|
| Other Form: |
Print version: Nuclear receptors. New York : Oxford University Press, 1999 0199637431 0199637423 (DLC) 99024782 (OCoLC)40954218 |
| ISBN |
0585483728 (electronic book) |
|
9780585483726 (electronic book) |
|
1280375698 |
|
9781280375699 |
|
