| Description |
1 online resource (574 pages). |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
RSC catalysis series ; 32
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RSC catalysis series ; no. 32.
|
| Note |
Includes index. |
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Title from title details screen. |
| Contents |
Cover; Preface; Contents; Section I: Accessing New Enzymes; Chapter 1 Genome Mining for Enzyme Discovery; 1.1 Introduction; 1.2 Text-based Searches Using Enzyme Name; 1.3 Sequence-driven Approaches; 1.3.1 Probe Technology Based on PCR Primer Design; 1.3.2 Pairwise Sequence Alignment-based Strategy; 1.3.3 Signature-/Key Motif-based Strategy; 1.4 3D Structure-guided Approach; 1.4.1 Exploring 3D Structures of Proteins; 1.4.2 Active Site Topology/Constellation-guided Strategy; 1.5 Conclusion; References; Chapter 2 Exploiting Natural Diversity for Industrial Enzymatic Applications |
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2.1 Introduction2.2 Screening Enzymes from Soil Microbes, Plants, and Animals (Millipede) by Activity Measurement; 2.2.1 Hydrolases; 2.2.2 Oxidoreductases; 2.2.3 Lyases; 2.3 Genetic Approaches to Natural Enzyme Sources; 2.3.1 Isomerases; 2.3.2 Oxidoreductases; 2.4 Creation of Amine Oxidase by Directed Evolution of D-Amino Acid Oxidase; 2.5 From Discovery to Application -- Aldoxime Dehydratases; 2.5.1 Isolation, Characterization and Comparison of Aldoxime Dehydratases; 2.5.2 Iron Heme Redox Catalysis and Mechanistic Studies; 2.5.3 Substrate Spectrum of Aldoxime Dehydratases |
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2.5.4 Application of Oxds for Nitrile Synthesis2.5.5 Perspectives; 2.6 Conclusion; Acknowledgements; References; Chapter 3 Artificial Metalloenzymes; 3.1 Introduction; 3.2 Direct Insertion of Inorganic Metal Ions into Proteins; 3.2.1 Carbonic Anhydrase; 3.2.2 Ferritin; 3.2.3 Serum Albumins; 3.2.4 Phytase and Other Proteins; 3.3 Supramolecular Anchoring of Metal Cofactors; 3.3.1 The ""Trojan-Horse"" Strategy; 3.3.2 The ""Host-Guest"" Strategy; 3.4 Covalent Linking of Metallic Cofactors to a Protein; 3.5 Cascade Reactions; 3.6 Conclusion; References |
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Chapter 4 Computational Enzyme Design: Successes, Challenges, and Future Directions4.1 Introduction; 4.2 Examples of Computational Enzyme Design; 4.2.1 Phase I: Initial Application of CPD Towards Enzyme Design; 4.2.2 Phase II: Incorporation of TransitionStates and Theozymes into Computational Enzyme Design; 4.3 Challenges in Computational Enzyme Design; 4.4 Future Directions; 4.5 Conclusions; Acknowledgements; References; Section II: Understanding and Engineering Enzymes; Chapter 5 Computational Techniques for Efficient Biocatalysis; 5.1 Introduction to Computational Biocatalysis |
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5.1.1 Bioinformatic Tools5.1.2 Ancestral Gene Resurrection; 5.1.3 Structure-based Computational Tools; 5.1.4 QM Computational Tools; 5.1.5 Molecular Mechanics and Molecular Dynamics Computational Tools; 5.1.6 QM/MM; 5.2 Implementation of Computational Tools in Biocatalysis; 5.2.1 Identification of Novel Biocatalysts from Sequence Space; 5.2.2 Ancestral Enzyme Reconstruction for theStudy and Engineering of Binding and Catalysis; 5.3 Structural-based In Silico Modelling for Efficient Biocatalysis |
| Summary |
With contributions from leading academics around the world, this book makes a ground-breaking contribution to the field of biocatalysis and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Biocatalysis.
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Biocatalysis. |
| Genre/Form |
Electronic books.
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| Added Author |
Williams, Gavin (Professor of chemistry), editor.
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Hall, Mélanie, 1980- editor.
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| Other Form: |
Print version: 9781782627265 |
| ISBN |
9781788010450 (electronic book) |
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1788010450 (electronic book) |
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9781788014533 |
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1788014537 |
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9781523119431 (electronic book) |
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1523119438 (electronic book) |
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9781782627265 (print) |
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178262726X (print) |
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