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Title Computational approaches to nuclear receptors / edited by Pietro Cozzini, Glen E. Kellogg.

Publication Info. Cambridge, U.K. : Royal Society of Chemistry, 2012.

Item Status

Description 1 online resource (xiii, 176 pages) : illustrations.
Physical Medium polychrome
Description text file
Series RSC drug discovery series, 2041-3203 ; no. 30
RSC drug discovery series ; 30.
Bibliography Includes bibliographical references and index.
Summary "Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several 'omics' projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors."-- Provided by publisher.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Nuclear receptors (Biochemistry)
Nuclear receptors (Biochemistry)
Nuclear receptors (Biochemistry) -- Data processing.
Receptors, Cytoplasmic and Nuclear.
Computers, Molecular.
Models, Biological.
Genre/Form Electronic books.
Electronic books.
Added Author Cozzini, Pietro.
Kellogg, Glen E.
Other Form: Print version: Computational approaches to nuclear receptors. Cambridge : RSC Publishing, ©2012 9781849733649 (OCoLC)821677937
ISBN 9781849735353 (electronic book)
1849735352 (electronic book)
9781849733649 (hardback)
1849733643 (hardback)