| Description |
1 online resource (458 pages). |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
RSC drug discovery series ; 76
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RSC drug discovery series ; 76.
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| Contents |
Intro -- Title -- Copyright -- Contents -- Chapter 1 Quest for Magic Bullets to Solve the Endocannabinoid Puzzle -- 1.1 Introduction -- 1.2 The Complex Endocannabinoid System -- 1.3 The Challenge of Designing Effective Drugs -- Acknowledgements -- References -- Chapter 2 Phytocannabinoids Versus Endocannabinoids. A Modern View of the Endocannabinoid System -- 2.1 From the Cannabis Plant to the Identification of the Endocannabinoid System -- 2.2 Overview of the Endocannabinoid Signaling System -- 2.2.1 Cannabinoid Receptors -- 2.2.2 Endocannabinoid Ligands -- 2.2.3 Endocannabinoid Synthesis |
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2.2.4 Endocannabinoid Inactivation -- 2.2.5 Endocannabinoids as Precursors of Novel Signaling Lipids -- 2.3 Conclusions and Future Perspectives -- References -- Chapter 3 Natural Compounds and Synthetic Drugs to Target Type-1 Cannabinoid (CB1) Receptor -- 3.1 Introduction -- 3.2 Phytocannabinoids and Classical/Non-classical and Other Analogues -- 3.2.1 Phytocannabinoids -- 3.2.2 Classical Cannabinoids -- 3.2.3 Non-classical Cannabinoids and Other Analogues -- 3.2.4 Other Approaches in Classical Cannabinoids -- 3.3 Endocannabinoids and Endogenous-like Analogues |
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3.3.1 Endogenous-like Derivatives with Enhanced Metabolic Stability -- 3.3.2 Hybrid Endocannabinoid Probes -- 3.3.3 Other Endocannabinoid Probes -- 3.4 Miscellaneous Synthetic Cannabinoids -- 3.5 Neutral Antagonists and Inverse Agonists -- 3.6 Allosteric Modulators -- 3.7 Conclusions -- Acknowledgements -- References -- Chapter 4 Natural Compounds and Synthetic Drugs to Target Type-2 Cannabinoid (CB2) Receptor -- 4.1 Cannabinoid Receptor Type-2 -- 4.2 CB2R Ligands -- 4.2.1 Endogenous Cannabinoids and Related Fatty Acid Derivatives -- 4.2.2 Phytocannabinoids -- 4.2.3 Synthetic Cannabinoids |
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4.2.4 Clinically Evaluated CB2R Agonists -- 4.2.5 Allosteric Ligands -- 4.2.6 Summary -- 4.3 Structural Biology and Structural Elucidation of CB2R -- 4.4 Chemical CB2R Probes -- 4.4.1 Radioligands and PET Tracers -- 4.4.2 Fluorescently Labeled Ligands -- 4.4.3 Covalent and Photoaffinity Probes -- 4.5 Conclusions and Outlook -- Abbreviations -- Dedication -- Acknowledgements -- References -- Chapter 5 Natural and Synthetic Cannabinoids Targeting Non-CB1, Non-CB2 G Protein-coupled Receptors -- 5.1 Introduction -- 5.2 GPR55 -- 5.2.1 General Features -- 5.2.2 Biological Relevance |
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5.2.3 Cannabinoids Targeting GPR55 -- 5.3 GPR18 -- 5.3.1 General Features -- 5.3.2 Biological Relevance -- 5.3.3 Cannabinoids Targeting GPR18 -- 5.4 GPR3/6/12 -- 5.4.1 General Features -- 5.4.2 Biological Relevance -- 5.4.3 Cannabinoids Targeting GPR3/6/12 -- 5.5 Other GPCRs Related to Cannabinoids -- 5.5.1 Well-established GPCRs -- 5.5.2 Orphan or Recently Deorphanized Receptors -- 5.6 Conclusions -- Acknowledgements -- References -- Chapter 6 Natural Compounds and Synthetic Drugs Targeting the Ionotropic Cannabinoid Members of Transient Receptor Potential (TRP) Channels -- 6.1 Introduction -- 6.2 TRPV Channels. |
| Summary |
New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds. This timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Cannabinoids -- Therapeutic use.
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Cannabinoids -- Therapeutic use. |
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Cannabinoids. |
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Cellular signal transduction.
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Cellular signal transduction. |
| Genre/Form |
Electronic books.
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| Added Author |
Maccarrone, Mauro, 1962-
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| Other Form: |
Print version: Maccarrone, Mauro. New Tools to Interrogate Endocannabinoid Signalling : From Natural Compounds to Synthetic Drugs. Cambridge : Royal Society of Chemistry, ©2020 9781788018012 |
| ISBN |
1839160853 (electronic book) |
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9781839160851 (electronic book) |
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9781839160752 (PDF ebook) |
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1839160756 |
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178801801X |
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9781788018012 |
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