| Description |
1 online resource. |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
RSC drug discovery ; v.33
|
|
RSC drug discovery series ; v.33.
|
| Summary |
This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Biochemical markers.
|
|
Biochemical markers. |
|
Biomarkers. |
| Genre/Form |
Electronic books.
|
| Added Author |
Horvatovich, Péter, 1972-
|
|
Bischoff, Rainer, 1956-
|
| ISBN |
9781849734363 (electronic book) |
|
1849734364 (electronic book) |
|
9781849734226 |
|
1849734224 |
|
