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Title Anti-inflammatory drug discovery / edited by Jeremy I. Levin, Stefan Laufer.

Publication Info. Cambridge, U.K. : Royal Society of Chemistry, [2012]
©2012

Item Status

Description 1 online resource (xv, 528 pages) : illustrations (some color).
Physical Medium polychrome
Description text file
Series RSC drug discovery series, 2041-3203 ; 26
RSC drug discovery series ; 26. 2041-3203
Bibliography Includes bibliographical references and index.
Summary Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medicinal chemistry literature for each target, ranging from components of the arachadonic acid cascade, to kinases, GPCRs, sphingolipids and others, to summarize its background biology and detail new insights, major advances and issues related to bringing new anti-inflammatory therapies to market. Consisting of five main sections key targets covered will include the AA Cascade: mPGES1, cPLA2, Leukotriene A4 Hydrolase, CRTH2; Kinases: P38/PDE4, MAPKAP Kinase 2 (MK2), Syk Kinase Inhibitors, Jak Kinases, IKK, Bruton's Tyrosine Kinase; GPCRs: CCR1, CCR2 Antagonists, CB2 Agonists; Sphingolipids: S1P1 Receptor Agonists, Sphingosine Lyase and Sphingosine Kinase 1 and a final miscellaneous section that looks at Non-Steroidal Dissociated Glucocorticoid Receptor Agonists. The book will be essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in industry and academia."-- Provided by publisher.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Anti-inflammatory agents -- Research.
Anti-inflammatory agents.
Research.
Anti-inflammatory agents -- Therapeutic use -- Technological innovations.
Technological innovations.
Inflammation -- Treatment -- Research.
Inflammation.
Genre/Form Electronic books.
Electronic books.
Added Author Levin, Jeremy I.
Laufer, Stefan.
Other Form: Print version: Anti-inflammatory drug discovery 9781849734134 (OCoLC)794035667 (OCoLC)794035667
ISBN 9781849735346 (electronic book)
1849735344 (electronic book)
9781849734134 (print)
1849734135 (print)