| Description |
1 online resource. |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
RSC Drug Discovery ; 4
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RSC drug discovery series ; 4.
|
| Summary |
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening ""hits"" as well as rational, structure-based design. The chapters include ""follow-ons"" and ""next generation"" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal. |
| Contents |
Discovery of the dipeptidyl peptidase-4 (DPP4) inhibitor Onglyza : from concept to market / Jeffrey A. Robl and Lawrence G. Hamann -- Discovery of Vorapaxar (SCH 530348), a thrombin receptor (protease activated receptor-1) antagonist with potent antiplatelet effects / Samuel Chackalamannil -- Discovery of Piragliatin, a glucokinase activator / Ramakanth Sarabu, Jefferson W. Tilley and Joseph Grimsby -- Discovery of OSI-906, a small-molecule inhibitor of the insulin-like growth factor-1 and insulin receptors / Mark J. Mulvihill and Elizabeth Buck -- Genesis of the antibody conjugate gemtuzumab ozogamicin (Mylotarg®) for acute myeloid leukemia / Philip R. Hamann -- Novel androgen receptor antagonists for the treatment of prostate cancer / Ashvinikumar V. Gavai, William R. Foster, Aaron Balog and Gregory D. Vite -- Discovery of UK-390957 : Challenge of targeting a short half-life, rapid Tmax SSRI / Mark D. Andrews and Donald S. Middleton -- Discovery of the long-acting PDE5 inhibitor PF-489791 for the treatment of pulmonary hypertension / Andrew S. Bell and Michael J. Palmer -- From HTS to market : Discovery and development of maraviroc, a CCR5 antagonist for the treatment of HIV / Chris Barber and David Pryde -- Discovery of GS-9131, an amidate prodrug of a novel nucleoside phosphate HIV reverse transcriptase inhibitor / Richard Mackman -- 2'-F-2'-C-methyl nucleosides and nucleotides for the treatment of hepatitis C virus : from discovery to the clinic / Michael J. Sofia, Phillip A. furman and William T. Symonds -- A case history on the challenges of central nervous system and dual pharmacology drug discovery / Paul V. Fish, Anthony Harrison, Florian Wakenhut and Gavin A. Whitlock -- Discovery of TRPV1 antagonists : turning up the heat / Mark H. Norman -- Uncoupling neuroprotection from immunosuppression : Discovery of ILS-920 / Edmund I. Graziani -- Identification of [alpha] 7 nicotinic acetylcholine receptor agonists for their assessment in improving cognition in schizophrenia / Bruce N. Rogers [and others]. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Drug development -- Case studies.
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Drug development. |
| Genre/Form |
Case studies.
|
| Subject |
Pharmaceutical chemistry -- Case studies.
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Pharmaceutical chemistry. |
| Genre/Form |
Electronic books.
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Case studies.
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| Added Author |
Barrish, Joel Charles, 1957-
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Carter, Percy.
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Zahler, Robert.
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| Other Form: |
Print version: Accounts in drug discovery. Cambridge : Royal Society of Chemistry, [2010], ©2011 9781849731263 1849731268 (OCoLC)671469689 |
| ISBN |
9781849731980 (electronic book) |
|
1849731985 (electronic book) |
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9781849731263 |
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1849731268 |
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