Skip to content
You are not logged in |Login  
     
Limit search to available items
Record:   Prev Next
Resources
More Information
Bestseller
BestsellerE-book

Title MicroRNAs in diseases and disorders : emerging therapeutic targets / edited by Philip V. Peplow, Bridget Martinez, George A. Calin and Aurora Esquela-Kercher.

Publication Info. Croydon, UK : Royal Society of Chemistry, [2019]
©2019

Item Status

Description 1 online resource (xx, 480 pages) : illustrations.
Physical Medium polychrome
Description text file
Series Drug discovery series ; 69
RSC drug discovery series ; 69.
Bibliography Includes bibliographical references and index.
Contents Intro; HalfTitle; series Editor; Title; Preface; Dedication; Copyright; Contents; Chapter 1 Role of Nutrition, the Epigenome, and MicroRNAs in Cancer Pathogenesis 1; 1.1 Introduction; 1.2 Epigenetic Link to Cancer; 1.3 miRNAs are Closely Associated with Human Cancer; 1.3.1 miRNA Biogenesis is Complex; 1.3.2 miRNAs as Tumor Suppressors and Oncogenic Factors; 1.3.3 Extracellular Delivery of miRNAs; 1.4 miRNAs and the Epigenome; 1.4.1 miRNAs that Regulate the Epigenetic Machinery; 1.4.2 miRNAs Targeted by the Epigenetic Machinery; 1.5 miRNAs, Dietary Factors, and the Epigenome; 1.5.1 Resveratrol
1.5.2 Ellagitannins and Ellagic Acid1.5.3 Epigallocatechin-3-gallate; 1.5.4 Genistein; 1.5.5 Curcumin; 1.5.6 Diindolylmethane; 1.6 miRNAs, the Microbiota, and Colon Cancer; 1.6.1 Microbial-produced Butyrate Influences Host miRNA Expression; 1.6.2 Butyrate Acts as a Histone Deacetylase Inhibitor in Cancer Cells; 1.6.3 Anti-tumor Effects of Butyrate and miRNA Expression in the Colon; 1.6.4 Butyrate's Role in Liver Cancer, the Epigenome, and miRNAs; 1.7 Plant-derived XenomiRs Impact Cancer Pathways in Human Cells; 1.7.1 Ingested Plant miRNAs Regulate Recipient Cell Targets
1.7.2 Plant miRNAs Impact Cancer Gene Expression1.8 Conclusion; Acknowledgements; References; Chapter 2 Role of MicroRNAs in Metabolic Diseases 36; 2.1 Introduction; 2.1.1 The Innate Immune System in Obesity-mediated Insulin Resistance and T2DM; 2.1.2 miRNAs and the Etiology of T2DM; 2.2 miR-122 is Elevated in Obesity and Human Metabolic Disease; 2.3 miR-126 is Downregulated in T2DM and Human Metabolic Disease; 2.4 miR-146a is Downregulated in Human Obesity and Diabetic Kidney Disease; 2.5 miR-155 is Downregulated in Human Obesity and NAFLD
2.6 miR-21 is Differentially Expressed in Obesity, T2DM, and Human Metabolic Syndrome2.7 miR-223 is Important in T2DM, Although Reports Conflict on Direction of Differential Expression; 2.8 miR-27a is Elevated in T2DM; 2.9 miR-29a is Elevated in T2DM; 2.10 miR-34a is Elevated in Obesity and T2DM; 2.11 miR-375 is Elevated in T2DM; 2.12 miRNAs as Biomarkers in Metabolic Disease; Acknowledgements; References; Chapter 3 Circulating MicroRNAs as Biomarkers of Celiac Disease and Other Intestinal Pediatric Diseases: Experimental and Bioinformatics Challenges From Bench to Bedside 76
3.1 Introduction3.1.1 Biogenesis and Regulatory Functions of miRNAs; 3.1.2 Biogenesis, Stability and Cellular Recognition of Circulating miRNAs; 3.1.3 Circulating miRNAs and Toll-like Receptors; 3.1.4 The Role of miRNAs in Intestinal Development and Homeostasis; 3.2 Celiac Disease; 3.3 Intestinal miRNAs of Celiac Disease Patients; 3.4 Circulating miRNAs of Celiac Disease Patients; 3.5 Regulation of Post-transcriptional Gene Expression by miRNAs in Celiac Disease; 3.6 Circulating miRNAs in Inflammatory Bowel Disease; 3.7 Experimental and Bioinformatics Challenges for miRNA Analysis
Summary MicroRNAs in Diseases and Disorders highlights the role of miRNAs in the development and progression of a variety of diseases and the utilization of miRNA targets in treatment. This book also includes the use of miRNAs as diagnostic and prognostic biomarkers for disease.
Local Note eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America
Subject Medical genetics.
Medical genetics.
MicroRNA.
MicroRNA.
Genre/Form Electronic books.
Added Author Peplow, Philip (Philip V.), editor.
Martinez, Bridget, editor.
Calin, George A. (George Adrian), editor.
Esquela-Kerscher, Aurora, editor.
Other Form: Print version : 9781788013949
ISBN 9781788017817 (electronic book)
1788017811 (electronic book)
9781788016421 (electronic book)
1788016424 (electronic book)
9781788013949
1788013948