| Description |
1 online resource (301 pages). |
| Physical Medium |
polychrome |
| Description |
text file |
| Series |
Metallobiology ; 12
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RSC metallobiology series ; 12.
|
| Note |
Includes index. |
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Title from title details screen. |
| Contents |
Cover; Preface; Contents; Chapter 1 Overview of Gasotransmitters and the Related Signaling Network; 1.1 Conceptualization and Evaluation Systems for Gasotransmitters; 1.2 Gasotransmitters -- Why Does the Terminology Matter?; 1.3 The Gasotransmitter Signaling Network in Eukaryotes; 1.3.1 Interaction of Gasotransmitters with Their Producers; 1.3.2 Interaction of Gasotransmitters with Their Users/Targets; 1.3.3 Interaction of Gasotransmitters with Their Sensors; 1.3.4 Interactions Between Gasotransmitters; Acknowledgements; References; Chapter 2 Production of NO -- The L-arginine/NOS/NO System |
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2.1 Introduction2.2 Biosynthesis and Sources of NO; 2.2.1 Biosynthesis of NO from L-arginine; 2.2.2 Synthesis of NO from Inorganic Nitrates; 2.2.3 Biosynthesis of NO from Homoarginine; 2.3 Regulation of NO Production; 2.3.1 Spatial Compartmentalization and Localization; 2.3.2 Modulation at the Level of Enzymatic Activity; 2.3.3 Metabolic Control of NO Production; 2.3.4 Regulation by Arginases; 2.3.5 Regulation by Arginine Transport; 2.4 Dysregulation of NO Disposition and Disease; 2.4.1 Nitric Oxide and Cardiovascular Disease; 2.4.2 Nitric Oxide and the Reproductive System |
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2.4.3 Nitric Oxide and Neurodegeneration2.5 Concluding Remarks; Acknowledgements; References; Chapter 3 Production of H2S -- The L-cysteine/CSE-CBS-MST/H2S System; 3.1 Introduction to H2S in Mammalian Cells; 3.2 Production of H2S in Mammalian Cells Involving CSE; 3.3 Production of H2S in Mammalian Cells Involving CBS; 3.4 Production of H2S in Mammalian Cells Involving MST; 3.4.1 Discovery of H2S Production by MST; 3.4.2 Mechanisms for H2S Production by MST; 3.4.3 Tissue Distribution of MST; 3.4.4 Regulation of H2S Production by MST |
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3.5 Relationship between the Production of H2S and Polysulfide3.6 Non-enzymatic H2S Production in Mammalian Cells; 3.6.1 Release of H2S from Bound Sulfur; 3.6.2 H2S Production from Organic Polysulfides by Thiol Reactions; 3.6.3 H2S Production by Human Erythrocytes; 3.7 Exogenous H2S Donors in Mammalian Cells; 3.7.1 Naturally Occurring Donors of H2S; 3.7.2 Synthetic H2S Donors; References; Chapter 4 HO-1-derived CO Is a Regulator of Vascular Function and Metabolic Syndrome; 4.1 Introduction; 4.2 Formation of CO; 4.3 Role of Excessive Heme in Obesity: HO-1-derived CO |
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4.4 Actions of CO on the Vasculature4.5 CO and the Regulation of Blood Pressure; 4.6 Metabolic Syndrome and Heme Metabolism; 4.7 Mitochondrial Dysfunction in Metabolic Syndrome; 4.8 Regulatory Role of HO-1 in Mitochondrial Function and Oxidative Phosphorylation; 4.9 Oxidative Stress and Mitochondrial Dysfunction; 4.10 HO-1 Gene Targeting in Obesity and Hypertension; 4.11 Bioactive Role of Biliverdin/Bilirubin; 4.12 Bioactive Role of Iron and Ferritin; 4.13 Therapeutic Potential of the EET-Heme-HO-1-derived CO/Bilirubin; 4.14 Concluding Remarks; Acknowledgements; References |
| Summary |
This book provides for the first time a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002 for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicology. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Cellular signal transduction.
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Cellular signal transduction. |
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Eukaryotic cells.
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Eukaryotic cells. |
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Prokaryotes.
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Prokaryotes. |
| Genre/Form |
Electronic books.
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| Added Author |
Wang, Xuerui, editor.
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| Other Form: |
Print version: Gasotransmitters. Cambridge : Royal Society of Chemistry, 2018 1782629246 9781782629245 (OCoLC)1023082813 |
| ISBN |
9781788013000 (electronic book) |
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178801300X (electronic book) |
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9781782629245 (print) |
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1782629246 |
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