| Description |
1 online resource (225 pages). |
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text file |
| Series |
Science Studies
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Science studies.
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| Contents |
Cover; Table of contents; Preface; 1 The lock-and-key analogy and its influence on 20th century biochemistry; 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907; 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930; 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960; 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs; 6 Concluding remarks on the construction of analogy-based research programs; Literature |
| Summary |
When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. |
| Access |
Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK). WlAbNL |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Language |
In English. |
| Terms Of Use |
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL |
| Subject |
History.
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History. |
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Spangenburg, Ray, 1939- History of science.
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Medicine.
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Medicine. |
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Science -- Social aspects.
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Science -- Social aspects. |
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Life sciences.
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Life sciences. |
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Science -- Philosophy.
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Science -- Philosophy. |
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Biochemistry.
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Biochemistry. |
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Analogy.
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Analogy. |
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Faculty series (University of Georgia. Division of Agricultural Economics)
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Molecular biology.
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Molecular biology. |
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Mathematical models.
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Mathematical models. |
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Medicine -- History -- 18th century.
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| Chronological Term |
18th century |
| Subject |
history (discipline) |
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medicines (material) |
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biological sciences. |
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biochemistry. |
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analogy. |
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molecular biology. |
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mathematical models. |
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HISTORY -- General. |
| Genre/Form |
Electronic books.
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| Other Form: |
Print version: Mertens, Rebecca. Construction of Analogy-Based Research Programs : The Lock-and-Key Analogy in 20th Century Biochemistry. Bielefeld : Transcipt Verlag, ©2019 9783837644425 |
| ISBN |
383944442X |
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9783839444429 (electronic book) |
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9783837644425 (print) |
| Standard No. |
10.14361/9783839444429. |
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