| Description |
1 online resource (xviii, 456 pages) : illustrations |
| Physical Medium |
polychrome |
| Description |
text file |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
From "nonentity" to global network: the rise of a new style of biomedical practice -- An early career in clinical oncology -- About this book -- A capsule history of cancer clinical trials -- Cancer clinical trials as a new style of practice -- The protocol -- Before there were trials -- Cancer hospitals and cancer institutes -- Diagnosing cancer -- Treating cancer -- Prognosticating cancer -- Testing therapies -- The emergence of clinical cancer research (1955-66) -- A landmark clinical trial -- Curing leukemia: the vamp trial -- A collective undertaking -- The elements of innovation -- What about the patients? -- The collective turn: cooperative groups as epistemic organizations -- Assembling the US cooperative system -- Screening for drugs: from mice to humans -- Tinkering with the cooperative group structure -- Meanwhile in Europe -- Clinical trial statistics -- What is a random sample? -- What is statistical significance? -- Statisticians, statistics, and early cooperative clinical trials -- Statisticians at the NIH -- Statisticians in Paris -- Fabricating the tools of the trade -- Controversial methods -- The emergence of the phase system -- Criticism and the redefinition of clinical cancer trials as an autonomous form of research -- Clinical cancer research under fire -- The reorganization of screening and clinical trials in the United States -- Surgery and radiotherapy in the cooperative groups -- An avalanche of numbers from the new style of practice (1965-89) -- A web of trials -- Breast cancer and its trials -- The lessons of the breast cancer trials -- The emergence of combination chemotherapy -- The multiple meanings of breast cancer trials -- Statisticians, data centers, and the organization of large-scale clinical trials -- Centers of calculation: us statisticians and the data center -- The mechanics of data production -- Meanwhile in Europe, take two -- Back in the USA: group statisticians and NCI statisticians -- Insiders' dissent: the randomization debate -- A relational space of substances and regimens -- The clinical evaluation of substances -- Screening substances: the animal screen -- Procuring compounds -- Oncopolitics? reshaping collaborative research -- Centralization or coordination? the European debate -- Clinical trials as clinical research: the US debate -- Oncology in the community -- Targeted therapy, targeted trials (1990-2006) -- Second interlude: molecular biology and oncogenes -- The rise of molecular biology -- Cancer and molecular biology: 1960-80 -- The clinical isolation of human oncogenes -- Oncogenes and oncoproteins since 1982 -- Magic bullets? the Gleevec trials -- Molecular biology and targeted substances -- The trials of a targeted therapy -- Where did Gleevec come from? -- Monitoring data, managing risks -- A medical oncologist and his patients -- Patients and activists -- Targeted therapy and clinical cancer research -- Introduction: molecular biology and translational research -- Molecular biology and the US cooperative groups -- The reorganization of the drug discovery process and the transformation of the NCI screen -- Clinical trials in a targeted age -- More oncopolitics -- Looking back and looking forward -- The observational alternative to clinical cancer trials -- Comparative effectiveness and clinical trials. |
| Summary |
This title charts the emergence of a clinical field - medical oncology - for which experimental protocols have become routinized as a form of normal practice. |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Oncology -- Research.
|
|
Oncology -- Research. |
|
Oncology. |
|
Cancer -- Research.
|
|
Cancer -- Research. |
|
Clinical Trials as Topic -- history. |
|
Medical Oncology -- history. |
|
Molecular Targeted Therapy -- history. |
|
Neoplasms -- therapy. |
|
Europe. |
|
United States. |
| Genre/Form |
Electronic books.
|
| Added Author |
Cambrosio, Alberto, 1950-
|
| Other Form: |
Print version: Keating, Peter, 1953- Cancer on trial. Chicago : The University of Chicago Press, ©2012 9780226428918 (DLC) 2011019445 (OCoLC)713181629 |
| ISBN |
9780226428932 (electronic book) |
|
0226428931 (electronic book) |
|
9786613362612 |
|
6613362611 |
|
1283362619 |
|
9781283362610 |
|
0226428915 (cloth alkaline paper) |
|
9780226428918 (cloth ; alkaline paper) |
|
