| Edition |
Fourth edition. |
| Description |
1 online resource (xxxvii, pages) : illustrations (chiefly color), color portraits |
|
text file |
| Note |
Revised edition of: Vitamin D / editor-in-chief, David Feldman; associate editors, J. Wesley Pike, John S. Adams. 3rd ed. 2011. |
| Bibliography |
Includes bibliographical references. |
| Contents |
Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position. |
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Contents note continued: Renin-Angiotensin System -- Vitamin D Regulation of the Renin-Angiotensin System -- Vitamin D and the Renin-Angiotensin System in Disease -- Conclusion -- References -- 46. Parathyroid Hormone, Parathyroid Hormone--Related Protein, and Calcitonin / John J. Wysolmerski -- Parathyroid Hormone -- Parathyroid Hormone--Related Protein -- Calcitonin -- References -- 47. FGF23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity / L. Darryl Quarles -- Introduction -- Parathyroid Hormone--Vitamin D Axis: Key Regulator of Calcium Homeostasis -- Fibroblast Growth Factor-23/α-Klotho -- Fibroblast Growth Factor-23 Endocrine Networks -- Noncanonical α-Klotho and Fibroblast Growth Factor-23 Signaling -- Conclusions -- References -- VI. DIAGNOSIS AND MANAGEMENT -- 48. Approach to the Patient With Metabolic Bone Disease / Michael P. Whyte -- Introduction -- Diagnostic Evaluation -- Biochemical Investigation -- Histopathological Assessment -- Treatment -- Conclusions -- Acknowledgments -- References -- 49. Detection of 1,25-Dihydroxyvitamin D in Human Serum Using Receptor Assisted Chemiluminescent Hormone Assay Technology / Bruce W. Hollis -- Introduction -- Methodology -- Identification of the DNA Consensus Sequence of the Immunoglobulin G VH and VL Gene, Expressed by Hybridoma Clone 11B4 -- Preparation of the Assay Reagents -- Assay Format and Performance -- Discussion -- References -- 50. Mass Spectrometry Assays of Vitamin D Metabolites / Ravinder J. Singh -- Introduction -- Approaches and Utility of Vitamin D Metabolite Measurements in the Clinical Laboratory Setting -- Overview of Methodology for Analysis of Circulating Vitamin D Metabolites by LC-MS/MS -- Application of LC-MS/MS to the Study of Vitamin D Metabolism in Animal Models -- Future Directions -- References -- 51. Free Vitamin D: Concepts, Assays, Outcomes, and Prospects / Carrie M. Nielson -- Introduction -- Metabolism -- Transportation and Internalization: Free Hormone Hypothesis and Bioavailable Ligand -- Vitamin D-Binding Protein Genotype -- Free Vitamin D: Mathematical Estimation -- Free Vitamin D: Direct Physical Measurement -- Potential Utility of Free 25(OH)D for Clinical- and Population-Based Detection of Vitamin D Deficiency -- Conclusions and Knowledge Gaps -- References -- 52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation / Neil C. Binkley -- Introduction -- Vitamin D Standardization Program Objectives -- Standardization and Traceability -- Vitamin D Standardization Program Standardization Protocols -- Performance Testing/Quality Assessment of Assays for Vitamin D Metabolites -- Vitamin D Standardization Program Efforts Going Into the Future -- Summary and Conclusions -- References -- 53. Bone Histomorphometry / David W. Dempster -- Introduction -- Bone Biopsy -- Histomorphometry -- Assessment of Mineralization -- Histological Diagnosis of Osteomalacia -- Assessment of Bone Turnover -- Assessment of Remodeling Balance -- Assessment of Bone Structure -- Influence of Vitamin D Status on Bone Histomorphometry -- Future Developments -- References -- 54. Radiology of Rickets and Osteomalacia / Judith E. Adams -- Introduction and Historical Aspects -- Vitamin D Deficiency -- Renal Osteodystrophy -- Renal Tubular Defects and Hypophosphatemia -- Differential Diagnoses -- Vitamin D Intoxication -- Conclusions -- References -- 55. High-Resolution Imaging Techniques for Bone Quality Assessment / Sharmila Majumdar -- Introduction -- X-ray Computed Tomography -- Magnetic Resonance Imaging -- References -- 56. Role of Vitamin D in Orthopedic Surgery / Joseph M. Lane -- Introduction -- Impact on Orthopedic Trauma -- Impact on Pediatric Orthopedics -- Impact on Total Joint Arthroplasty -- References -- Introduction to Chapters 57A and 57B References -- 57A. IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position / Cliff Rosen -- Introduction -- Vitamin D Status and Bone Health in Adults and the Elderly -- Vitamin D and Extraskeletal Health -- Lessons From Recently Updated Guidelines on Vitamin D Supplementation -- Vitamin D and Human Health: What is the Optimal Vitamin D Status -- Summary of Recommendations -- Highlights -- References -- 57B. IOM---Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position / Michael F. Holick -- Section I Defining the Disagreement Between IOM and Endocrine Society -- Section II Scientific Basis for Why IOM Versus Endocrine Society Values Differ in Terms of Bone Health -- Section III Toxicity and Perceptions of Risk of Higher Vitamin D Intakes: Higher-Dose Clinical Trials and Epidemiology U-Shaped Risk Findings -- Section IV Extraskeletal Effects of Vitamin D -- Section V Extraskeletal Effects: Cross-Sectional Observations Versus the Findings of Double-Blind, Randomized Clinical Trials -- Section VI Emerging Benefits of Higher Vitamin D: Life Expectancy -- Section VII New Evidence That Vitamin D Lowers Risk of Preterm Birth -- Section VIII Conclusion. |
| Summary |
"Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description |
| Local Note |
eBooks on EBSCOhost EBSCO eBook Subscription Academic Collection - North America |
| Subject |
Vitamin D.
|
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Vitamin D. |
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MEDICAL -- Physiology. |
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology. |
| Genre/Form |
Electronic books.
|
| Added Author |
Feldman, David, 1939- editor.
|
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Pike, J. Wesley, editor.
|
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Bouillon, R., editor.
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| Added Title |
Biochemistry, physiology and diagnostics |
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Companion to: Vitamin D. Volume 2, Health, disease and therapeutics.
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Preceded by: Vitamin D. 3rd ed.
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| Other Form: |
Print version: Vitamin D. |
| ISBN |
9780128099667 (electronic book) |
|
0128099666 (electronic book) |
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9780128099650 (hardcover) |
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0128099658 (hardcover) |
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