LEADER 00000cam a2200841Ia 4500 
001    ocn794327677 
003    OCoLC 
005    20190405013554.5 
006    m     o  d         
007    cr cnu---unuuu 
008    120528s2012    enk     ob    001 0 eng d 
019    794707324|a817920069 
020    9781139379489|q(electronic book) 
020    1139379488|q(electronic book) 
020    9781139375191 
020    1139375199 
020    9781139045582|q(electronic book) 
020    113904558X|q(electronic book) 
020    |z9781139376624 
020    |z1139376624 
020    |z9780521768238|q(Cloth) 
020    |z0521768233|q(Cloth) 
024 8  9786613640789 
035    (OCoLC)794327677|z(OCoLC)794707324|z(OCoLC)817920069 
040    EBLCP|beng|epn|cEBLCP|dOCLCQ|dCDX|dN$T|dYDXCP|dE7B|dOCLCQ
       |dDEBSZ|dCAMBR|dOCLCQ|dD6H|dOCLCQ|dOCLCO|dOCLCA|dCOO|dBUF
       |dOCLCO|dUUM|dOCLCF|dOCLCO|dOCLCQ|dOCLCA 
049    RIDW 
050  4 QH505 
072  7 SCI|x009000|2bisacsh 
082 04 571.401/13|a571.40113|222 
084    TEC009000|2bisacsh 
090    QH505 
100 1  Beard, Daniel A.,|d1971-|0https://id.loc.gov/authorities/
       names/no98065538 
245 10 Biosimulation :|bsimulation of living systems /|cDaniel A.
       Beard. 
264  1 Cambridge ;|aNew York :|bCambridge University Press,
       |c2012. 
300    1 online resource. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc 
347    text file|2rdaft 
490 1  Cambridge texts in biomedical engineering 
504    Includes bibliographical references and index. 
505 0  Cover; Biosimulation; Series; Title; Copyright; Contents; 
       Preface; Extracts; 1: Introduction to simulation of 
       biological systems; Overview; 1.1 Modeling approaches; 1.2
       An introductory example: biochemistry of a home aquarium; 
       1.2.1 First model: a nonmechanistic analysis; 1.2.2 
       Nonmechanistic analysis with noise; 1.2.3 Mechanistic 
       modeling; 1.3 Recapitulation and lessons learned; 
       Problems; 2: Transport and reaction of solutes in 
       biological systems; Overview; 2.1 Well-mixed systems: 
       compartmental modeling; 2.2 Passive flow of water, solutes,
       and electrical current across membranes. 
505 8  2.2.1 Basic equations2.2.2 Example: volume changes in 
       isolated glomeruli; 2.3 Simulating chemical reactions; 
       2.3.1 Example: synthesis of ethanol from xylose; 2.4 
       Distributed transport modeling; 2.4.1 Flowing systems: the
       advection equation; 2.4.2 Reaction-diffusion systems; 
       2.4.3 Advection-reaction-diffusion systems; 2.5 
       Recapitulation and lessons learned; Problems; 3: 
       Physiologically based pharmacokinetic modeling; Overview; 
       3.1 Introduction to lumped compartmental PBPK modeling; 
       3.1.1 Basic equations; 3.1.2 Comparison of distributed and
       lumped transport models. 
505 8  3.1.3 Quasi-steady model reduction3.1.4 Lumped versus 
       distributed transport modeling: a final word; 3.2 Overview
       of the mammalian circulatory system; 3.3 Whole-body PBPK 
       simulation; 3.4 Example: uptake and delivery of matrine in
       rat; 3.4.1 A PBPK model for rat; 3.4.2 Model parameters; 
       3.4.3 Flow-limited transport; 3.4.4 Model validation and 
       discrimination; 3.5 Recapitulation and lessons learned; 
       Problems; 4: Cardiovascular systems simulation; Overview; 
       4.1 The Frank-Starling mechanism of heart; 4.2 An analysis
       of the physiological factors that control cardiac output. 
505 8  4.2.1 Guyton's model of the systemic circulation4.2.2 What
       the model tells us about the relationship between flow and
       right atrial pressure; 4.2.3 How the simple Guyton model 
       is commonly misinterpreted; 4.3 Pulsatile mechanics of the
       circulatory system; 4.3.1 Time-varying elastance models of
       the heart; 4.3.2 Simulation of the aortic pressure 
       waveform; 4.4 Dynamic changes in blood pressures and 
       flows; 4.4.1 Baroreceptor control of systemic pressure; 
       4.5 Mechanisms of hypertension; 4.6 Recapitulation and 
       lessons learned; Problems. 
505 8  5: Chemical reaction systems: thermodynamics and chemical 
       equilibriumOverview; 5.1 Temperature, pressure, and 
       entropy; 5.1.1 Microstates and macrostates; 5.1.2 Example:
       a simple two-state system; 5.1.3 Relationship between 
       temperature and entropy; 5.1.4 Relationship between 
       pressure and entropy; 5.2 Free energy under constant-
       temperature and constant-volume conditions; 5.3 Free 
       energy under constant-temperature and constant-pressure 
       conditions; 5.4 Thermodynamic ensembles, partition 
       functions, and driving forces; 5.5 Chemical reactions, 
       stoichiometry, and equilibrium constants; 5.6 Acids, bases,
       and buffers. 
520    A hands-on guide to devising, designing and analyzing 
       simulations of biophysical processes for applications in 
       biological and biomedical sciences. 
588 0  Print version record. 
590    eBooks on EBSCOhost|bEBSCO eBook Subscription Academic 
       Collection - North America 
650  0 Biophysics|0https://id.loc.gov/authorities/subjects/
       sh85014253|xComputer simulation.|0https://id.loc.gov/
       authorities/subjects/sh99005300 
650  0 Biophysics|0https://id.loc.gov/authorities/subjects/
       sh85014253|xSimulation methods.|0https://id.loc.gov/
       authorities/subjects/sh99005303 
650  0 Biomedical engineering|0https://id.loc.gov/authorities/
       subjects/sh85014237|xComputer simulation.|0https://
       id.loc.gov/authorities/subjects/sh99005300 
650  0 Medical sciences|0https://id.loc.gov/authorities/subjects/
       sh85083022|vCase studies.|0https://id.loc.gov/authorities/
       subjects/sh99001484 
650  7 Biophysics.|2fast|0https://id.worldcat.org/fast/832656 
650  7 Computer simulation.|2fast|0https://id.worldcat.org/fast/
       872518 
650  7 Simulation methods.|2fast|0https://id.worldcat.org/fast/
       1119166 
650  7 Biomedical engineering|xComputer simulation.|2fast|0https:
       //id.worldcat.org/fast/832569 
650  7 Biomedical engineering.|2fast|0https://id.worldcat.org/
       fast/832568 
650  7 Medical sciences.|2fast|0https://id.worldcat.org/fast/
       1014601 
655  2 Case Reports.|0https://id.nlm.nih.gov/mesh/D002363 
655  4 Electronic books. 
655  7 Case studies.|2fast|0https://id.worldcat.org/fast/1423765 
655  7 Case studies.|2lcgft|0https://id.loc.gov/authorities/
       genreForms/gf2017026140 
776 08 |iPrint version:|aBeard, Daniel A., 1971-|tBiosimulation.
       |dCambridge ; New York : Cambridge University Press, 2012
       |z9780521768238|w(DLC)  2011046839|w(OCoLC)761858511 
830  0 Cambridge texts in biomedical engineering.|0https://
       id.loc.gov/authorities/names/no2007047067 
856 40 |uhttps://rider.idm.oclc.org/login?url=http://
       search.ebscohost.com/login.aspx?direct=true&scope=site&
       db=nlebk&AN=443737|zOnline eBook via EBSCO. Access 
       restricted to current Rider University students, faculty, 
       and staff. 
856 42 |3Instructions for reading/downloading the EBSCO version 
       of this eBook|uhttp://guides.rider.edu/ebooks/ebsco 
901    MARCIVE 20231220 
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994    92|bRID