LEADER 00000cam a2200685Mu 4500 001 on1202480440 003 OCoLC 005 20220114043859.0 006 m o d 007 cr cnu---unuuu 008 201031s2020 si o ||| 0 eng d 019 1200197704|a1202449622 020 9811454078 020 9789811454073|q(electronic book) 035 (OCoLC)1202480440|z(OCoLC)1200197704|z(OCoLC)1202449622 040 EBLCP|beng|cEBLCP|dEBLCP|dYDX|dUKAHL|dN$T|dOCLCF 049 RIDW 050 4 RM315 066 |c(S 082 04 615.78|223 090 RM315 245 00 Medicinal Chemistry of Drugs Affecting the Nervous System. 264 1 Singapore :|bBentham Science Publishers,|c2020. 300 1 online resource (406 pages). 336 text|btxt|2rdacontent 337 computer|bc|2rdamedia 338 online resource|bcr|2rdacarrier 340 |gpolychrome|2rdacc 347 text file|2rdaft 490 1 Medicinal Chemistry for Pharmacy Students Ser. 500 Description based upon print version of record. 505 0 Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Drugs Affecting the Cholinergic System -- Cory R. Theberge1, Kim Lindsey-Goodrich2 and Ashok E. Philip3,* -- HISTORICAL PERSPECTIVES -- INTRODUCTORY CONCEPTS -- Choline and Acetylcholine -- Acetylcholine and Neurotransmission -- Cholinergic Neurochemistry: ACh Biosynthesis, Storage, Release, and Metabolism -- Cholinergic Receptors -- Muscarinic and Nicotinic Subtypes -- Clinical Use of Acetylcholine -- MUSCARINIC RECEPTOR AGONISTS -- MUSCARINIC RECEPTOR ANTAGONISTS (ANTICHOLINERGICS) 505 8 Donepezil (Aricept®) -- Pharmacokinetics -- Side effects/ Drug Interactions -- Rivastigmine (Exelon®) 2000, Oral -- 2008, Patch -- Pharmacokinetics -- Side effects/Drug Interactions -- Galantamine (Razadyne®) 2001 -- Pharmacokinetics -- Side effects/Drug-interactions -- NMDA Receptor Antagonist: Memantine (Namenda®) 2003 -- Pharmacokinetics -- Side effects/Drug interactions -- Place in Therapy -- CASE STUDY -- What therapeutic modifications would you make at this time and why? -- Drug Discovery Case Study -- The Quaternary Advantage -- Ipratropium and the Kinetic Selectivity of Tiotropium 505 8 STUDENT SELF STUDY GUIDE -- PRACTICE QUESTIONS -- NOTES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Drugs Affecting Adrenergic System -- M. O. Faruk1,* and Les Ramos2 -- HISTORICAL BACKGROUND -- THE INTRODUCTORY CONCEPTS -- Adrenergic Neurotransmitters -- Adrenergic Receptors (ARs) -- DRUGS AFFECTING ADRENERGIC SYSTEM: STRUCTURES, ACTIVITY, METABOLISM AND RELATED THERAPEUTIC CONSIDERATIONS -- The Antiadrenergics Affecting Synthesis, Storage, or Release of NE (Fig. 7) -- Metyrosine -- Reserpine -- Mechanism of Action -- Pharmacokinetics 520 The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second volume of the series and it presents 8 chapters focusing on a comprehensive account of drugs affecting the nervous system. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detail structure activity relationships and metabolism as w. 590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic Collection - North America 650 0 Neuropharmacology.|0https://id.loc.gov/authorities/ subjects/sh85091157 650 0 Autonomic nervous system|0https://id.loc.gov/authorities/ subjects/sh85090938|xEffect of drugs on.|0https:// id.loc.gov/authorities/subjects/sh00004603 650 0 Central nervous system|0https://id.loc.gov/authorities/ subjects/sh85021906|xEffect of drugs on.|0https:// id.loc.gov/authorities/subjects/sh00004603 650 0 Pharmaceutical chemistry.|0https://id.loc.gov/authorities/ subjects/sh85023026 650 7 Neuropharmacology.|2fast|0https://id.worldcat.org/fast/ 1036458 650 7 Autonomic nervous system.|2fast|0https://id.worldcat.org/ fast/824152 650 7 Central nervous system|xEffect of drugs on.|2fast|0https:/ /id.worldcat.org/fast/850741 650 7 Central nervous system.|2fast|0https://id.worldcat.org/ fast/850724 650 7 Pharmaceutical chemistry.|2fast|0https://id.worldcat.org/ fast/1060115 655 4 Electronic books. 700 1 Faruk, M. O. 700 1 Philip, Ashok E. 776 08 |iPrint version:|aFaruk, M. O.|tMedicinal Chemistry of Drugs Affecting the Nervous System|dSingapore : Bentham Science Publishers,c2020|z9789811454059 830 0 Medicinal Chemistry for Pharmacy Students Ser. 856 40 |uhttps://rider.idm.oclc.org/login?url=https:// search.ebscohost.com/login.aspx?direct=true&scope=site& db=nlebk&AN=2649039|zOnline ebook via EBSCO. Access restricted to current Rider University students, faculty, and staff. 856 42 |3Instructions for reading/downloading the EBSCO version of this ebook|uhttp://guides.rider.edu/ebooks/ebsco 880 |6500-00/(S|aTherapeutic Evaluation of the Imidazoline α Adrenergic Agonists 880 8 |6505-00/(S|aGuanethidine and Guanadrel -- Direct-Acting Sympathomimetic Agents -- The General Mechanism and SAR of β-Phenylethylamine Derivatives (Direct and Indirect Acting Agonists) -- Sar 1 -- Sar 2 -- Sar 3 -- Sar 4 -- Sar 5 -- Sar 6 -- Sar 7 -- Sar 8 -- Sar 9 -- Therapeutic Evaluation of the β-Phenylethylamine Direct Acting Adrenergic Agonists -- β2 Adrenergic Agonist and Cardiac Function -- Long Acting β2-Adrenoceptor Agonists (LABAs) -- β3 Adrenergic Receptor Agonist -- The General SAR of Imidazolines (α Adrenergic Agonist and Antagonists) -- Sar 1 -- Sar 2 -- Sar 3 880 8 |6505-00/(S|aAcetylcholinesterase (AChE) Inhibitors -- Reversible Noncovalent Inhibitors -- Reversible Covalent Inhibitors -- Irreversible Covalent Inhibitors -- NEUROMUSCULAR BLOCKING AGENTS -- Depolarizing Muscle Nicotinic Receptor Neuromuscular Blocking Agents -- Non- depolarizing Muscle Nicotinic Receptor Neuromuscular Blocking Agents -- Ganglionic-Nicotinic Receptor Blocking Agents -- TREATMENT OF ALZHEIMER'S DISEASE (AD) -- Epidemiology -- Pathophysiology -- β-Amyloid Hypothesis -- Cholinergic Hypothesis -- Other Hypothesis -- Pharmacotherapy -- Acetyl Cholinesterase (AChE) Inhibitors 901 MARCIVE 20231220 948 |d20220127|cEBSCO|tEBSCOebooksacademic NEW 6019|lridw 994 92|bRID