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001 on1041854598
003 OCoLC
005 20200110050929.6
006 m o d
007 cr cnu|||unuuu
008 180625s2018 enk o 001 0 eng d
015 GBB873321|2bnb
015 GBB8I4455|2bnb
016 7 018838870|2Uk
016 7 019064573|2Uk
019 1041484637
020 9781788010450|q(electronic book)
020 1788010450|q(electronic book)
020 9781788014533
020 1788014537
020 9781523119431|q(electronic book)
020 1523119438|q(electronic book)
020 |z9781782627265|q(print)
020 |z178262726X|q(print)
035 (OCoLC)1041854598|z(OCoLC)1041484637
037 4771:4623|bRoyal Society of Chemistry|nhttp://www.rsc.org/
spr
040 UKRSC|beng|erda|epn|cUKRSC|dN$T|dCOO|dEBLCP|dUIU|dMERER
|dOCLCF|dOCLCQ|dNLE|dSTF|dUAB|dUKMGB|dLVT|dERL|dKNOVL|dESU
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049 RIDW
050 4 TP248.25.B55
072 7 SCI|x013040|2bisacsh
072 7 PSB|2bicssc
072 7 TCB|2bicssc
082 04 547/.215|223
090 TP248.25.B55
245 00 Modern biocatalysis :|badvances towards synthetic
biological systems /|ceditors: Gavin Williams, Mélanie
Hall.
264 1 Cambridge :|bRoyal Society of Chemistry,|c2018.
300 1 online resource (574 pages).
336 text|btxt|2rdacontent
337 computer|bc|2rdamedia
338 online resource|bcr|2rdacarrier
340 |gpolychrome|2rdacc
347 text file|2rdaft
490 1 RSC catalysis series ;|v32
500 Includes index.
500 Title from title details screen.
505 0 Cover; Preface; Contents; Section I: Accessing New
Enzymes; Chapter 1 Genome Mining for Enzyme Discovery; 1.1
Introduction; 1.2 Text-based Searches Using Enzyme Name;
1.3 Sequence-driven Approaches; 1.3.1 Probe Technology
Based on PCR Primer Design; 1.3.2 Pairwise Sequence
Alignment-based Strategy; 1.3.3 Signature-/Key Motif-based
Strategy; 1.4 3D Structure-guided Approach; 1.4.1
Exploring 3D Structures of Proteins; 1.4.2 Active Site
Topology/Constellation-guided Strategy; 1.5 Conclusion;
References; Chapter 2 Exploiting Natural Diversity for
Industrial Enzymatic Applications
505 8 2.1 Introduction2.2 Screening Enzymes from Soil Microbes,
Plants, and Animals (Millipede) by Activity Measurement;
2.2.1 Hydrolases; 2.2.2 Oxidoreductases; 2.2.3 Lyases; 2.3
Genetic Approaches to Natural Enzyme Sources; 2.3.1
Isomerases; 2.3.2 Oxidoreductases; 2.4 Creation of Amine
Oxidase by Directed Evolution of D-Amino Acid Oxidase; 2.5
From Discovery to Application -- Aldoxime Dehydratases;
2.5.1 Isolation, Characterization and Comparison of
Aldoxime Dehydratases; 2.5.2 Iron Heme Redox Catalysis and
Mechanistic Studies; 2.5.3 Substrate Spectrum of Aldoxime
Dehydratases
505 8 2.5.4 Application of Oxds for Nitrile Synthesis2.5.5
Perspectives; 2.6 Conclusion; Acknowledgements;
References; Chapter 3 Artificial Metalloenzymes; 3.1
Introduction; 3.2 Direct Insertion of Inorganic Metal Ions
into Proteins; 3.2.1 Carbonic Anhydrase; 3.2.2 Ferritin;
3.2.3 Serum Albumins; 3.2.4 Phytase and Other Proteins;
3.3 Supramolecular Anchoring of Metal Cofactors; 3.3.1 The
""Trojan-Horse"" Strategy; 3.3.2 The ""Host-Guest""
Strategy; 3.4 Covalent Linking of Metallic Cofactors to a
Protein; 3.5 Cascade Reactions; 3.6 Conclusion; References
505 8 Chapter 4 Computational Enzyme Design: Successes,
Challenges, and Future Directions4.1 Introduction; 4.2
Examples of Computational Enzyme Design; 4.2.1 Phase I:
Initial Application of CPD Towards Enzyme Design; 4.2.2
Phase II: Incorporation of TransitionStates and Theozymes
into Computational Enzyme Design; 4.3 Challenges in
Computational Enzyme Design; 4.4 Future Directions; 4.5
Conclusions; Acknowledgements; References; Section II:
Understanding and Engineering Enzymes; Chapter 5
Computational Techniques for Efficient Biocatalysis; 5.1
Introduction to Computational Biocatalysis
505 8 5.1.1 Bioinformatic Tools5.1.2 Ancestral Gene
Resurrection; 5.1.3 Structure-based Computational Tools;
5.1.4 QM Computational Tools; 5.1.5 Molecular Mechanics
and Molecular Dynamics Computational Tools; 5.1.6 QM/MM;
5.2 Implementation of Computational Tools in Biocatalysis;
5.2.1 Identification of Novel Biocatalysts from Sequence
Space; 5.2.2 Ancestral Enzyme Reconstruction for theStudy
and Engineering of Binding and Catalysis; 5.3 Structural-
based In Silico Modelling for Efficient Biocatalysis
520 With contributions from leading academics around the world,
this book makes a ground-breaking contribution to the
field of biocatalysis and is essential reading for
graduates and researchers investigating (bio)catalysis,
enzyme engineering, chemical biology, and synthetic
biology.
590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic
Collection - North America
650 0 Biocatalysis.|0https://id.loc.gov/authorities/subjects/
sh2013002148
650 7 Biocatalysis.|2fast|0https://id.worldcat.org/fast/1896571
655 4 Electronic books.
700 1 Williams, Gavin|c(Professor of chemistry),|0https://
id.loc.gov/authorities/names/n2018188415|eeditor.
700 1 Hall, Mélanie,|d1980-|0https://id.loc.gov/authorities/
names/n2018188417|eeditor.
776 08 |iPrint version:|z9781782627265
830 0 RSC catalysis series ;|0https://id.loc.gov/authorities/
names/no2008189149|vno. 32.
856 40 |uhttps://rider.idm.oclc.org/login?url=http://
search.ebscohost.com/login.aspx?direct=true&scope=site&
db=nlebk&AN=1841267|zOnline eBook via EBSCO. Access
restricted to current Rider University students, faculty,
and staff.
856 42 |3Instructions for reading/downloading the EBSCO version
of this eBook|uhttp://guides.rider.edu/ebooks/ebsco
901 MARCIVE 20231220
948 |d20200122|cEBSCO|tEBSCOebooksacademic NEW 12-21,1-17
11948|lridw
994 92|bRID
