LEADER 00000cam a2200649Ia 4500 
001    ocn821854592 
003    OCoLC 
005    20160527040727.8 
006    m     o  d         
007    cr cn||||||||| 
008    121218s2012    enka    ob    001 0 eng d 
016 7  016107782|2Uk 
019    814441528 
020    9781849735353|q(electronic book) 
020    1849735352|q(electronic book) 
020    |z9781849733649|q(hardback) 
020    |z1849733643|q(hardback) 
035    (OCoLC)821854592|z(OCoLC)814441528 
037    T3736|bRoyal Society of Chemistry|nhttp://www.rsc.org/spr 
040    UKRSC|beng|epn|cUKRSC|dOCLCO|dAU@|dYDXCP|dMYG|dN$T|dE7B
       |dIUL|dNJR|dDEBSZ|dOCLCQ 
049    RIDW 
050  4 QH603.C43|bC66 2012eb 
072  7 SCI|x049000|2bisacsh 
082 04 572.88450285|223 
090    QH603.C43|bC66 2012eb 
245 00 Computational approaches to nuclear receptors /|cedited by
       Pietro Cozzini, Glen E. Kellogg. 
264  1 Cambridge, U.K. :|bRoyal Society of Chemistry,|c2012. 
300    1 online resource (xiii, 176 pages) :|billustrations. 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
340    |gpolychrome|2rdacc 
347    text file|2rdaft 
490 1  RSC drug discovery series,|x2041-3203 ;|vno. 30 
504    Includes bibliographical references and index. 
520    "Nuclear receptors (NR) are ligand-induced activated 
       transcription factors that are involved in numerous 
       biological processes. Since the 1990's when the first 
       structures were determined by means of X ray diffraction, 
       the number of NR structures has increased considerably. 
       Moreover several 'omics' projects (genomics, 
       pharmcogenomics and proteomics) have opened up great 
       opportunities for the discovery of new targets, the 
       characterization of abnormal protein patterns, the 
       selection of "tailored" drugs and the evaluation of drug 
       efficacy even with a lack of structural data. Furthermore,
       structure-based drug design, computational methods for in 
       silico screening and nanobiotechnology- based tools are 
       simplifying this time-consuming and money-intensive 
       research of lead compounds and, possibly, new drugs. 
       Biological interactions such as those that occur between a
       protein and ligand are concerted events where flexible 
       molecules interact. Thus understanding flexibility of 
       large molecules or biological complexes is of primary 
       importance to help define the right model to approximate 
       the reality for drug discovery, virtual screening, food 
       safety analysis, etc. NRs are known as flexible targets, 
       with many structural similarities, in particular for their
       Ligand Binding Domain: these similarities could be assumed
       to share behavioural qualities that belong to this class 
       of compounds. Thus to supply a possible, complete and 
       exhaustive answer to questions about the behaviour of NRs,
       their interactions with new potential drugs, endocrine 
       disruptors such as animal and human food toxins, food 
       additives or industry residuals, it is mandatory to 
       approach the problem from a different point of view: a 
       molecular modelling approach, steered synthesis, and in 
       vitro and in vivo tests, etc. The aim of this book is to 
       provide a state of the art review on investigations into 
       Nuclear Receptors."--|cProvided by publisher. 
588 0  Print version record. 
590    eBooks on EBSCOhost|bEBSCO eBook Subscription Academic 
       Collection - North America 
650  0 Nuclear receptors (Biochemistry)|0https://id.loc.gov/
       authorities/subjects/sh96008334 
650  0 Nuclear receptors (Biochemistry)|0https://id.loc.gov/
       authorities/subjects/sh96008334|xData processing.|0https:/
       /id.loc.gov/authorities/subjects/sh99005487 
650  7 Nuclear receptors (Biochemistry)|2fast|0https://
       id.worldcat.org/fast/1040875 
650 12 Receptors, Cytoplasmic and Nuclear.|0https://
       id.nlm.nih.gov/mesh/D018160 
650 22 Computers, Molecular.|0https://id.nlm.nih.gov/mesh/D039301
650 22 Models, Biological.|0https://id.nlm.nih.gov/mesh/D008954 
655  0 Electronic books. 
655  4 Electronic books. 
700 1  Cozzini, Pietro.|0https://id.loc.gov/authorities/names/
       nb2012029731 
700 1  Kellogg, Glen E.|0https://id.loc.gov/authorities/names/
       nb2012029732 
776 08 |iPrint version:|tComputational approaches to nuclear 
       receptors.|dCambridge : RSC Publishing, ©2012
       |z9781849733649|w(OCoLC)821677937 
830  0 RSC drug discovery series ;|0https://id.loc.gov/
       authorities/names/no2010092643|v30. 
856 40 |uhttps://rider.idm.oclc.org/login?url=http://
       search.ebscohost.com/login.aspx?direct=true&scope=site&
       db=nlebk&AN=519390|zOnline eBook. Access restricted to 
       current Rider University students, faculty, and staff. 
856 42 |3Instructions for reading/downloading this eBook|uhttp://
       guides.rider.edu/ebooks/ebsco 
901    MARCIVE 20231220 
948    |d20160607|cEBSCO|tebscoebooksacademic|lridw 
994    92|bRID