LEADER 00000cam a2200649Ia 4500 001 ocn801422000 003 OCoLC 005 20160527040714.1 006 m o d 007 cr cnu|||||||| 008 120720s2012 enka ob 001 0 eng 019 843640702 020 9781849735346|q(electronic book) 020 1849735344|q(electronic book) 020 |z9781849734134|q(print) 020 |z1849734135|q(print) 035 (OCoLC)801422000|z(OCoLC)843640702 040 AU@|beng|epn|cAU@|dUIU|dUKRSC|dMYG|dOCLCQ|dYDXCP|dN$T |dDEBSZ|dMHW|dOCLCQ 049 RIDW 050 4 RM405|b.A58 2012eb 072 7 MED|x071000|2bisacsh 082 04 615.7/94|223 090 RM405|b.A58 2012eb 245 00 Anti-inflammatory drug discovery /|cedited by Jeremy I. Levin, Stefan Laufer. 264 1 Cambridge, U.K. :|bRoyal Society of Chemistry,|c[2012] 264 4 |c©2012 300 1 online resource (xv, 528 pages) :|billustrations (some color). 336 text|btxt|2rdacontent 337 computer|bc|2rdamedia 338 online resource|bcr|2rdacarrier 340 |gpolychrome|2rdacc 347 text file|2rdaft 490 1 RSC drug discovery series,|x2041-3203 ;|v26 504 Includes bibliographical references and index. 520 Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti- inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medicinal chemistry literature for each target, ranging from components of the arachadonic acid cascade, to kinases, GPCRs, sphingolipids and others, to summarize its background biology and detail new insights, major advances and issues related to bringing new anti-inflammatory therapies to market. Consisting of five main sections key targets covered will include the AA Cascade: mPGES1, cPLA2, Leukotriene A4 Hydrolase, CRTH2; Kinases: P38/PDE4, MAPKAP Kinase 2 (MK2), Syk Kinase Inhibitors, Jak Kinases, IKK, Bruton's Tyrosine Kinase; GPCRs: CCR1, CCR2 Antagonists, CB2 Agonists; Sphingolipids: S1P1 Receptor Agonists, Sphingosine Lyase and Sphingosine Kinase 1 and a final miscellaneous section that looks at Non-Steroidal Dissociated Glucocorticoid Receptor Agonists. The book will be essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in industry and academia."--|cProvided by publisher. 588 0 Print version record. 590 eBooks on EBSCOhost|bEBSCO eBook Subscription Academic Collection - North America 650 0 Anti-inflammatory agents|0https://id.loc.gov/authorities/ subjects/sh85005615|xResearch.|0https://id.loc.gov/ authorities/subjects/sh2002006576 650 0 Anti-inflammatory agents|0https://id.loc.gov/authorities/ subjects/sh85005615|xTherapeutic use|0https://id.loc.gov/ authorities/subjects/sh2001008985|xTechnological innovations.|0https://id.loc.gov/authorities/subjects/ sh2001009095 650 0 Inflammation|0https://id.loc.gov/authorities/subjects/ sh85066108|xTreatment|0https://id.loc.gov/authorities/ subjects/sh99005040|xResearch.|0https://id.loc.gov/ authorities/subjects/sh2002006576 650 7 Anti-inflammatory agents.|2fast|0https://id.worldcat.org/ fast/810354 650 7 Research.|2fast|0https://id.worldcat.org/fast/1095153 650 7 Technological innovations.|2fast|0https://id.worldcat.org/ fast/1145002 650 7 Inflammation.|2fast|0https://id.worldcat.org/fast/972432 655 0 Electronic books. 655 4 Electronic books. 700 1 Levin, Jeremy I.|0https://id.loc.gov/authorities/names/ n2012189799 700 1 Laufer, Stefan.|0https://id.loc.gov/authorities/names/ n2003130085 776 08 |iPrint version:|tAnti-inflammatory drug discovery |z9781849734134|w(OCoLC)794035667|w(OCoLC)794035667 830 0 RSC drug discovery series ;|0https://id.loc.gov/ authorities/names/no2010092643|v26.|x2041-3203 856 40 |uhttps://rider.idm.oclc.org/login?url=http:// search.ebscohost.com/login.aspx?direct=true&scope=site& db=nlebk&AN=519389|zOnline eBook. Access restricted to current Rider University students, faculty, and staff. 856 42 |3Instructions for reading/downloading this eBook|uhttp:// guides.rider.edu/ebooks/ebsco 901 MARCIVE 20231220 948 |d20160607|cEBSCO|tebscoebooksacademic|lridw 994 92|bRID